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==Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from Haemophilus influenzae==
==Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from Haemophilus influenzae==
<StructureSection load='4h2k' size='340' side='right' caption='[[4h2k]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
<StructureSection load='4h2k' size='340' side='right'caption='[[4h2k]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h2k]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Haein Haein]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H2K FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h2k]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Haemophilus_influenzae_Rd_KW20 Haemophilus influenzae Rd KW20]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H2K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H2K FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3isz|3isz]], [[3ic1|3ic1]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2k OCA], [https://pdbe.org/4h2k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h2k RCSB], [https://www.ebi.ac.uk/pdbsum/4h2k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2k ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">dapE, HI_0102 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=71421 HAEIN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Succinyl-diaminopimelate_desuccinylase Succinyl-diaminopimelate desuccinylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.18 3.5.1.18] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h2k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h2k OCA], [http://pdbe.org/4h2k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h2k RCSB], [http://www.ebi.ac.uk/pdbsum/4h2k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h2k ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DAPE_HAEIN DAPE_HAEIN]] Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. It can only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L-SDAP) and is inactive toward D,L-, L,D-, and D,D-SDAP.<ref>PMID:12962500</ref> <ref>PMID:16421726</ref> <ref>PMID:18712420</ref>
[https://www.uniprot.org/uniprot/DAPE_HAEIN DAPE_HAEIN] Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls. It can only hydrolyze L,L-N-succinyl-diaminopimelic acid (L,L-SDAP) and is inactive toward D,L-, L,D-, and D,D-SDAP.<ref>PMID:12962500</ref> <ref>PMID:16421726</ref> <ref>PMID:18712420</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Haein]]
[[Category: Haemophilus influenzae Rd KW20]]
[[Category: Succinyl-diaminopimelate desuccinylase]]
[[Category: Large Structures]]
[[Category: Holz, R]]
[[Category: Holz R]]
[[Category: Jedrzejczak, R]]
[[Category: Jedrzejczak R]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Structural genomic]]
[[Category: Makowska-Grzyska M]]
[[Category: Makowska-Grzyska, M]]
[[Category: Nocek B]]
[[Category: Nocek, B]]
[[Category: Starus A]]
[[Category: Starus, A]]
[[Category: Dape]]
[[Category: Hydrolase]]
[[Category: Mcsg]]
[[Category: Psi-biology]]
[[Category: Zinc-dependent hydrolase]]
Retrieved from "https://proteopedia.org/4h2k"