4h6u: Difference between revisions

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==Tubulin acetyltransferase mutant==
==Tubulin acetyltransferase mutant==
<StructureSection load='4h6u' size='340' side='right' caption='[[4h6u]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='4h6u' size='340' side='right'caption='[[4h6u]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h6u]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Brachidanio_rerio Brachidanio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H6U FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h6u]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Danio_rerio Danio rerio]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H6U FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACO:ACETYL+COENZYME+*A'>ACO</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">atat1, mec17, si:ch211-152p11.5, zgc:65893 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=7955 Brachidanio rerio])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h6u OCA], [https://pdbe.org/4h6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h6u RCSB], [https://www.ebi.ac.uk/pdbsum/4h6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h6u ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Alpha-tubulin_N-acetyltransferase Alpha-tubulin N-acetyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.108 2.3.1.108] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h6u OCA], [http://pdbe.org/4h6u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h6u RCSB], [http://www.ebi.ac.uk/pdbsum/4h6u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h6u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE]] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>
[https://www.uniprot.org/uniprot/ATAT_DANRE ATAT_DANRE] Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May promote directional cell locomotion and chemotaxis (By similarity). May be required for normal sperm flagellar function (By similarity). May affect microtubule stability and regulate microtubule dynamics. May be involved in neuron development. Acetylates alpha-tubulin in neurons, but not in cilia.[HAMAP-Rule:MF_03130]<ref>PMID:20829795</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Alpha-tubulin N-acetyltransferase|Alpha-tubulin N-acetyltransferase]]
*[[Alpha-tubulin N-acetyltransferase 3D structures|Alpha-tubulin N-acetyltransferase 3D structures]]
*[[Tubulin acetyltransferase|Tubulin acetyltransferase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Alpha-tubulin N-acetyltransferase]]
[[Category: Danio rerio]]
[[Category: Brachidanio rerio]]
[[Category: Large Structures]]
[[Category: Kizub, V]]
[[Category: Kizub V]]
[[Category: Roll-Mecak, A]]
[[Category: Roll-Mecak A]]
[[Category: Szyk, A]]
[[Category: Szyk A]]
[[Category: Transferase]]
[[Category: Tubulin acetyltransferase]]
Retrieved from "https://proteopedia.org/4h6u"