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==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==
==Crystal structure of the tetratricopeptide repeat (TPR) motif of human dual specificity protein kinase Mps1==
<StructureSection load='4h7x' size='340' side='right' caption='[[4h7x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='4h7x' size='340' side='right'caption='[[4h7x]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h7x]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H7X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H7X FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PB:LEAD+(II)+ION'>PB</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4h7y|4h7y]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [https://pdbe.org/4h7x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [https://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MPS1, MPS1L1, NCBI Reference Sequence NM_003318.4, TTK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dual-specificity_kinase Dual-specificity kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.1 2.7.12.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h7x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h7x OCA], [http://pdbe.org/4h7x PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h7x RCSB], [http://www.ebi.ac.uk/pdbsum/4h7x PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h7x ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN]] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>
[https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dual specificity protein kinase|Dual specificity protein kinase]]
*[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dual-specificity kinase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Blundell, T L]]
[[Category: Blundell TL]]
[[Category: Bolanos-Garcia, V M]]
[[Category: Bolanos-Garcia VM]]
[[Category: Chirgadze, D Y]]
[[Category: Chirgadze DY]]
[[Category: Cancer]]
[[Category: Chromosome instability]]
[[Category: Mitotic checkpoint]]
[[Category: Mitotic checkpoint kinase]]
[[Category: Transferase]]
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