4h98: Difference between revisions

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==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
==Candida glabrata dihydrofolate reductase complexed with NADPH and 5-{3-[3-(2,3-dihydro-1,4-benzodioxin-6-yl)-5-methoxyphenyl]prop-1-yn-1-yl}-6-ethylpyrimidine-2,4-diamine (UCP1018)==
<StructureSection load='4h98' size='340' side='right' caption='[[4h98]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
<StructureSection load='4h98' size='340' side='right'caption='[[4h98]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Canga Canga]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H98 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h98]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Candida_glabrata_CBS_138 Candida glabrata CBS 138]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H98 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14Q:5-{3-[3-(1,3-BENZODIOXOL-5-YL)-5-METHOXYPHENYL]PROP-1-YN-1-YL}-6-ETHYLPYRIMIDINE-2,4-DIAMINE'>14Q</scene>, <scene name='pdbligand=NDP:NADPH+DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NDP</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3roa|3roa]], [[3ro9|3ro9]], [[3qly|3qly]], [[3qlx|3qlx]], [[3qlz|3qlz]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [https://pdbe.org/4h98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [https://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CAGL0J03894g, DHFR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=284593 CANGA])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h98 OCA], [http://pdbe.org/4h98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h98 RCSB], [http://www.ebi.ac.uk/pdbsum/4h98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h98 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q6FPH0_CANGA Q6FPH0_CANGA]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Dihydrofolate reductase|Dihydrofolate reductase]]
*[[Dihydrofolate reductase 3D structures|Dihydrofolate reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Canga]]
[[Category: Large Structures]]
[[Category: Dihydrofolate reductase]]
[[Category: Anderson AC]]
[[Category: Anderson, A C]]
[[Category: Paulsen JL]]
[[Category: Paulsen, J L]]
[[Category: Antifungal agent]]
[[Category: Candida glabrata]]
[[Category: Drug design]]
[[Category: Enzyme inhibitor]]
[[Category: Fungal protein]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
[[Category: Tetrahydrofolate dehydrogenase]]
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