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==Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket==
==Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket==
<StructureSection load='4h9g' size='340' side='right' caption='[[4h9g]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
<StructureSection load='4h9g' size='340' side='right'caption='[[4h9g]], [[Resolution|resolution]] 1.93&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4h9g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"flavobacterium_thermophilum"_yoshida_and_oshima_1971 "flavobacterium thermophilum" yoshida and oshima 1971]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4H9G FirstGlance]. <br>
<table><tr><td colspan='2'>[[4h9g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_thermophilus Thermus thermophilus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4H9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4H9G FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=14J:5-BROMOFURAN-2-CARBOXYLIC+ACID'>14J</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=14J:5-BROMOFURAN-2-CARBOXYLIC+ACID'>14J</scene>, <scene name='pdbligand=GNP:PHOSPHOAMINOPHOSPHONIC+ACID-GUANYLATE+ESTER'>GNP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NH4:AMMONIUM+ION'>NH4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tuf, tufA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=274 "Flavobacterium thermophilum" Yoshida and Oshima 1971])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4h9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h9g OCA], [https://pdbe.org/4h9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4h9g RCSB], [https://www.ebi.ac.uk/pdbsum/4h9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4h9g ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Protein-synthesizing_GTPase Protein-synthesizing GTPase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.5.3 3.6.5.3] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4h9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4h9g OCA], [http://pdbe.org/4h9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4h9g RCSB], [http://www.ebi.ac.uk/pdbsum/4h9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4h9g ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/EFTU1_THETH EFTU1_THETH]] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.  
[https://www.uniprot.org/uniprot/EFTU1_THETH EFTU1_THETH] This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 20: Line 18:
</div>
</div>
<div class="pdbe-citations 4h9g" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4h9g" style="background-color:#fffaf0;"></div>
==See Also==
*[[Elongation factor 3D structures|Elongation factor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Flavobacterium thermophilum yoshida and oshima 1971]]
[[Category: Large Structures]]
[[Category: Protein-synthesizing GTPase]]
[[Category: Thermus thermophilus]]
[[Category: Groftehauge, M K]]
[[Category: Groftehauge MK]]
[[Category: Morth, J P]]
[[Category: Morth JP]]
[[Category: Nissen, P]]
[[Category: Nissen P]]
[[Category: Skrydstrup, T]]
[[Category: Skrydstrup T]]
[[Category: Taaning, R H]]
[[Category: Taaning RH]]
[[Category: Therkelsen, M]]
[[Category: Therkelsen M]]
[[Category: Gtp binding]]
[[Category: Gtpase]]
[[Category: P-loop]]
[[Category: Ribosome binding]]
[[Category: Translation]]
[[Category: Trna binding]]

Revision as of 08:05, 3 November 2022

Probing EF-Tu with a very small brominated fragment library identifies the CCA pocket

4h9g, resolution 1.93Å

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