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==Crystal structure of the telomeric Saccharomyces cerevisiae Cdc13 OB2 domain==
==Crystal structure of the telomeric Saccharomyces cerevisiae Cdc13 OB2 domain==
<StructureSection load='4hce' size='340' side='right' caption='[[4hce]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4hce' size='340' side='right'caption='[[4hce]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hce]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HCE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HCE FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hce]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HCE FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hce OCA], [https://pdbe.org/4hce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hce RCSB], [https://www.ebi.ac.uk/pdbsum/4hce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hce ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hce OCA], [http://pdbe.org/4hce PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hce RCSB], [http://www.ebi.ac.uk/pdbsum/4hce PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hce ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>
[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Harper, S]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Johnson, F B]]
[[Category: Harper S]]
[[Category: Mason, M]]
[[Category: Johnson FB]]
[[Category: Schultz, D C]]
[[Category: Mason M]]
[[Category: Skordalakes, E]]
[[Category: Schultz DC]]
[[Category: Speicher, D W]]
[[Category: Skordalakes E]]
[[Category: Wannat, J J]]
[[Category: Speicher DW]]
[[Category: Cell cycle]]
[[Category: Wannat JJ]]
[[Category: Ob fold]]
[[Category: Oligonucleotide/oligosaccharide binding fold]]
Retrieved from "https://proteopedia.org/4hce"