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==Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol==
==Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol==
<StructureSection load='4hd8' size='340' side='right' caption='[[4hd8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4hd8' size='340' side='right'caption='[[4hd8]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hd8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HD8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HD8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hd8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HD8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HD8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PIT:PICEATANNOL'>PIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene>, <scene name='pdbligand=IPA:ISOPROPYL+ALCOHOL'>IPA</scene>, <scene name='pdbligand=PIT:PICEATANNOL'>PIT</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=FDL:N~6~-ACETYL-N-(4-METHYL-2-OXO-2H-CHROMEN-7-YL)-L-LYSINAMIDE'>FDL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hd8 OCA], [https://pdbe.org/4hd8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hd8 RCSB], [https://www.ebi.ac.uk/pdbsum/4hd8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hd8 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hda|4hda]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SIR2L3, SIRT3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hd8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hd8 OCA], [http://pdbe.org/4hd8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hd8 RCSB], [http://www.ebi.ac.uk/pdbsum/4hd8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hd8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN]] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>
[https://www.uniprot.org/uniprot/SIR3_HUMAN SIR3_HUMAN] NAD-dependent protein deacetylase. Activates mitochondrial target proteins, including ACSS1, IDH2 and GDH by deacetylating key lysine residues. Contributes to the regulation of the cellular energy metabolism. Important for regulating tissue-specific ATP levels.<ref>PMID:16788062</ref> <ref>PMID:18680753</ref> <ref>PMID:18794531</ref> <ref>PMID:19535340</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Histone deacetylase|Histone deacetylase]]
*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Gertz, M]]
[[Category: Large Structures]]
[[Category: Nguyen, G T.T]]
[[Category: Gertz M]]
[[Category: Steegborn, C]]
[[Category: Nguyen GTT]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Steegborn C]]
[[Category: Inhibitor complex]]
[[Category: Mitochondrial]]
[[Category: Nad-dependent deacetylase]]
[[Category: Piceatannol]]
[[Category: Resveratrol-like compound]]
[[Category: Sirtuin]]

Revision as of 08:11, 3 November 2022

Crystal structure of human Sirt3 in complex with Fluor-de-Lys peptide and piceatannol

4hd8, resolution 2.30Å

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