4hf2: Difference between revisions
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==Crystal Structure of E43A IscR mutant bound to its promoter== | ==Crystal Structure of E43A IscR mutant bound to its promoter== | ||
<StructureSection load='4hf2' size='340' side='right' caption='[[4hf2]], [[Resolution|resolution]] 2.99Å' scene=''> | <StructureSection load='4hf2' size='340' side='right'caption='[[4hf2]], [[Resolution|resolution]] 2.99Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4hf2]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4hf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HF2 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hf2 OCA], [https://pdbe.org/4hf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hf2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hf2 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Escherichia coli]] | ||
[[Category: | [[Category: Escherichia coli K-12]] | ||
[[Category: Large Structures]] | |||
[[Category: Phillips KJ]] | |||
[[Category: Rajagopalan SR]] | |||
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