4hf2: Difference between revisions

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==Crystal Structure of E43A IscR mutant bound to its promoter==
==Crystal Structure of E43A IscR mutant bound to its promoter==
<StructureSection load='4hf2' size='340' side='right' caption='[[4hf2]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
<StructureSection load='4hf2' size='340' side='right'caption='[[4hf2]], [[Resolution|resolution]] 2.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hf2]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HF2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hf2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] and [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HF2 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4hf0|4hf0]], [[4hf1|4hf1]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hf2 OCA], [https://pdbe.org/4hf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hf2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hf2 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">iscR, yfhP, b2531, JW2515 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hf2 OCA], [http://pdbe.org/4hf2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hf2 RCSB], [http://www.ebi.ac.uk/pdbsum/4hf2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hf2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI]] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref>
[https://www.uniprot.org/uniprot/ISCR_ECOLI ISCR_ECOLI] Regulates the transcription of several operons and genes involved in the biogenesis of Fe-S clusters and Fe-S-containing proteins. Transcriptional repressor of the iscRSUA operon, which is involved in the assembly of Fe-S clusters into Fe-S proteins. In its apoform, under conditions of oxidative stress or iron deprivation, it activates the suf operon, which is a second operon involved in the assembly of Fe-S clusters. Represses its own transcription as well as that of toxin rnlA.<ref>PMID:11742080</ref> <ref>PMID:16824106</ref> <ref>PMID:20421606</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli]]
[[Category: Phillips, K J]]
[[Category: Escherichia coli K-12]]
[[Category: Rajagopalan, S R]]
[[Category: Large Structures]]
[[Category: Dna binding]]
[[Category: Phillips KJ]]
[[Category: Iron-sulfur cluster]]
[[Category: Rajagopalan SR]]
[[Category: Protein-dna complex]]
[[Category: Redox sensor]]
[[Category: Transcription-dna complex]]
[[Category: Transcriptional regulator]]
[[Category: Whth]]
[[Category: Winged helix-turn-helix]]