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==Crystal Structure of the Human SPOP C-terminal Domain==
==Crystal Structure of the Human SPOP C-terminal Domain==
<StructureSection load='4hs2' size='340' side='right' caption='[[4hs2]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
<StructureSection load='4hs2' size='340' side='right'caption='[[4hs2]], [[Resolution|resolution]] 1.53&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hs2]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HS2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HS2 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hs2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HS2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HS2 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SPOP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hs2 OCA], [https://pdbe.org/4hs2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hs2 RCSB], [https://www.ebi.ac.uk/pdbsum/4hs2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hs2 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hs2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hs2 OCA], [http://pdbe.org/4hs2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hs2 RCSB], [http://www.ebi.ac.uk/pdbsum/4hs2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hs2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN]] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>
[https://www.uniprot.org/uniprot/SPOP_HUMAN SPOP_HUMAN] Inhibits IPF1/PDX1 transactivation of established target promoters, such as insulin, may be by recruiting a repressor complex (By similarity). In complex with CUL3, involved in ubiquitination of BMI1, H2AFY and DAXX, and probably also in ubiquitination and proteasomal degradation of Gli2 or Gli3.<ref>PMID:14528312</ref> <ref>PMID:15897469</ref> <ref>PMID:16524876</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4hs2" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4hs2" style="background-color:#fffaf0;"></div>
==See Also==
*[[Speckle-type POZ protein 3D structures|Speckle-type POZ protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Carr, S B]]
[[Category: Large Structures]]
[[Category: Geersdaele, L K.Van]]
[[Category: Carr SB]]
[[Category: Stead, M A]]
[[Category: Stead MA]]
[[Category: Wright, S C]]
[[Category: Van Geersdaele LK]]
[[Category: Oligomerisation]]
[[Category: Wright SC]]
[[Category: Protein binding]]
[[Category: Protein interaction domain]]
Retrieved from "https://proteopedia.org/4hs2"