4hsc: Difference between revisions

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<StructureSection load='4hsc' size='340' side='right'caption='[[4hsc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4hsc' size='340' side='right'caption='[[4hsc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4hsc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Strpq Strpq]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4HSC FirstGlance]. <br>
<table><tr><td colspan='2'>[[4hsc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes_SSI-1 Streptococcus pyogenes SSI-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4HSC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4HSC FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">slo, SPs0132 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=193567 STRPQ])</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsc OCA], [https://pdbe.org/4hsc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4hsc RCSB], [https://www.ebi.ac.uk/pdbsum/4hsc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsc ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_nucleosidase NAD(+) nucleosidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.2.5 3.2.2.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4hsc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4hsc OCA], [http://pdbe.org/4hsc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4hsc RCSB], [http://www.ebi.ac.uk/pdbsum/4hsc PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4hsc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TACY_STRPQ TACY_STRPQ]] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).  
[https://www.uniprot.org/uniprot/TACY_STRPQ TACY_STRPQ] Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation (By similarity).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Strpq]]
[[Category: Streptococcus pyogenes SSI-1]]
[[Category: Feil, S C]]
[[Category: Feil SC]]
[[Category: Parker, M W]]
[[Category: Parker MW]]
[[Category: Cholesterol-dependent cytolysin]]
[[Category: Membrane insertion]]
[[Category: Membrane pore]]
[[Category: Pore-forming toxin]]
[[Category: Toxin]]
Retrieved from "https://proteopedia.org/4hsc"