4i29: Difference between revisions

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==Binary complex of mouse TdT with ssDNA and Mn++==
==Binary complex of mouse TdT with ssDNA and Mn++==
<StructureSection load='4i29' size='340' side='right' caption='[[4i29]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4i29' size='340' side='right'caption='[[4i29]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4i29]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I29 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4I29 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4i29]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4I29 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4I29 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8BA:8-BROMO-DEOXYADENOSINE-5-MONOPHOSPHATE'>8BA</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=8BA:8-BROMO-DEOXYADENOSINE-5-MONOPHOSPHATE'>8BA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4i29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i29 OCA], [https://pdbe.org/4i29 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4i29 RCSB], [https://www.ebi.ac.uk/pdbsum/4i29 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4i29 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4i27|4i27]], [[4i28|4i28]], [[4i2a|4i2a]], [[4i2b|4i2b]], [[4i2c|4i2c]], [[4i2d|4i2d]], [[4i2e|4i2e]], [[4i2f|4i2f]], [[4i2g|4i2g]], [[4i2h|4i2h]], [[4i2i|4i2i]], [[4i2j|4i2j]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Dntt, Tdt ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA_nucleotidylexotransferase DNA nucleotidylexotransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.31 2.7.7.31] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4i29 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4i29 OCA], [http://pdbe.org/4i29 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4i29 RCSB], [http://www.ebi.ac.uk/pdbsum/4i29 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4i29 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE]] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.  
[https://www.uniprot.org/uniprot/TDT_MOUSE TDT_MOUSE] Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA nucleotidylexotransferase]]
[[Category: Large Structures]]
[[Category: Lk3 transgenic mice]]
[[Category: Mus musculus]]
[[Category: Delarue, M]]
[[Category: Delarue M]]
[[Category: Gouge, J]]
[[Category: Gouge J]]
[[Category: Terminal transferase]]
[[Category: Transferase-dna complex]]
Retrieved from "https://proteopedia.org/4i29"