Sandbox Reserved 1741: Difference between revisions
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[[]]<Structure load='1REV' size='350' frame='true' align='right' caption='Note: This 3D structure should be showing Beta strands. We are currently trying to find a new structure on PBD.' scene='Insert optional scene name here' />{{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | [[]]<Structure load='1REV' size='350' frame='true' align='right' caption='Note: This 3D structure should be showing Beta strands. We are currently trying to find a new structure on PBD.' scene='Insert optional scene name here' />{{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==HIV-1 Reverse Transcriptase== | ==HIV-1 Reverse Transcriptase== | ||
'''Reverse Transcriptase''' (RT), also known as '''RNA-Directed DNA Polymerase''', is an enzyme used by retroviruses for the catalysis of the transcription of retrovirus RNA into DNA, which is the reverse of normal cellular transcription (DNA to RNA). HIV-1 RT is the reverse transcriptase used by the Human Immunodeficiency Virus and is what makes the virus so infectious once in the body. The discovery of HIV-1 RT was a landmark discovery, and the first drugs offered to people living with HIV-1 were inhibitors of HIV-1 RT. | '''Reverse Transcriptase''' (RT), also known as '''RNA-Directed DNA Polymerase''', is an enzyme used by retroviruses for the catalysis of the transcription of retrovirus RNA into DNA, which is the reverse of normal cellular transcription (DNA to RNA). HIV-1 RT is the reverse transcriptase used by the Human Immunodeficiency Virus and is what makes the virus so infectious once in the body. The discovery of HIV-1 RT was a landmark discovery, and the first drugs offered to people living with HIV-1 were inhibitors of HIV-1 RT (5). | ||
== Function == | == Function == | ||
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== Disease == | == Disease == | ||
Note: We plan to add a figure here from https://www.britannica.com/science/reverse-transcriptase | |||
== Relevance == | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
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== References == | == References == | ||
<references/> | <references/> | ||
Note: We will adjust the references to go in sequential order once we are finished with references, as we plan to add more information with more references looking forward. | |||
(1)Kati, W.M.; Johnson, K.A.; Jerver, L.F.; Anderson, K.F. Mechanism and Fidelity of HIV Reverse | (1)Kati, W.M.; Johnson, K.A.; Jerver, L.F.; Anderson, K.F. Mechanism and Fidelity of HIV Reverse | ||
Transcriptase. ''J. Biol. Chem.'' '''1992''', ''267''(36), 25988-25997 | Transcriptase. ''J. Biol. Chem.'' '''1992''', ''267''(36), 25988-25997 | ||
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(4)Hu, W. S.; Hughes, S. HIV-1 Reverse Transcription. ''Cold Spring Harb. Prospect. Med.'' '''2012''' ''2''(10) doi: 10.1101/cshperspect.a006882 | (4)Hu, W. S.; Hughes, S. HIV-1 Reverse Transcription. ''Cold Spring Harb. Prospect. Med.'' '''2012''' ''2''(10) doi: 10.1101/cshperspect.a006882 | ||
(5) Morier, D. Reverse transcriptase. https://www.britannica.com/science/reverse-transcriptase (accessed Nov 14, 2022). | |||
