8bfs: Difference between revisions

Revision as of 20:15, 16 November 2022

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326

Structural highlights

8bfs is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	EDO, QNR, SO4
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

KCC1D_HUMAN Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.^[1] ^[2] ^[3] ^[4]

References

↑ Verploegen S, Lammers JW, Koenderman L, Coffer PJ. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood. 2000 Nov 1;96(9):3215-23. PMID:11050006
↑ Verploegen S, Ulfman L, van Deutekom HW, van Aalst C, Honing H, Lammers JW, Koenderman L, Coffer PJ. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood. 2005 Aug 1;106(3):1076-83. Epub 2005 Apr 19. PMID:15840691 doi:https://dx.doi.org/10.1182/blood-2004-09-3755
↑ Sakagami H, Kamata A, Nishimura H, Kasahara J, Owada Y, Takeuchi Y, Watanabe M, Fukunaga K, Kondo H. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Eur J Neurosci. 2005 Dec;22(11):2697-707. PMID:16324104 doi:https://dx.doi.org/10.1111/j.1460-9568.2005.04463.x
↑ Kamata A, Sakagami H, Tokumitsu H, Owada Y, Fukunaga K, Kondo H. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res. 2007 Jan;57(1):86-97. Epub 2006 Oct 23. PMID:17056143 doi:https://dx.doi.org/10.1016/j.neures.2006.09.013

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OCA

[1] Verploegen S, Lammers JW, Koenderman L, Coffer PJ. Identification and characterization of CKLiK, a novel granulocyte Ca(++)/calmodulin-dependent kinase. Blood. 2000 Nov 1;96(9):3215-23. PMID:11050006

[2] Verploegen S, Ulfman L, van Deutekom HW, van Aalst C, Honing H, Lammers JW, Koenderman L, Coffer PJ. Characterization of the role of CaMKI-like kinase (CKLiK) in human granulocyte function. Blood. 2005 Aug 1;106(3):1076-83. Epub 2005 Apr 19. PMID:15840691 doi:https://dx.doi.org/10.1182/blood-2004-09-3755

[3] Sakagami H, Kamata A, Nishimura H, Kasahara J, Owada Y, Takeuchi Y, Watanabe M, Fukunaga K, Kondo H. Prominent expression and activity-dependent nuclear translocation of Ca2+/calmodulin-dependent protein kinase Idelta in hippocampal neurons. Eur J Neurosci. 2005 Dec;22(11):2697-707. PMID:16324104 doi:https://dx.doi.org/10.1111/j.1460-9568.2005.04463.x

[4] Kamata A, Sakagami H, Tokumitsu H, Owada Y, Fukunaga K, Kondo H. Spatiotemporal expression of four isoforms of Ca2+/calmodulin-dependent protein kinase I in brain and its possible roles in hippocampal dendritic growth. Neurosci Res. 2007 Jan;57(1):86-97. Epub 2006 Oct 23. PMID:17056143 doi:https://dx.doi.org/10.1016/j.neures.2006.09.013

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[4]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8bfs is ON HOLD
+==Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326==
+<StructureSection load='8bfs' size='340' side='right'caption='[[8bfs]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
-Authors: Kraemer, A., Zhu, W.F., Hernandez-Olmos, V., Proschak, E., Knapp, S., Structural Genomics Consortium (SGC)
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8bfs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BFS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BFS FirstGlance]. <br>
-Description: Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=QNR:3~{H}-pyrrolo[2,3-c]isoquinolin-5-amine'>QNR</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8bfs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8bfs OCA], [https://pdbe.org/8bfs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8bfs RCSB], [https://www.ebi.ac.uk/pdbsum/8bfs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8bfs ProSAT]</span></td></tr>
-[[Category: Proschak, E]]
+</table>
-[[Category: Knapp, S]]
+== Function ==
-[[Category: Hernandez-Olmos, V]]
+[https://www.uniprot.org/uniprot/KCC1D_HUMAN KCC1D_HUMAN] Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta.<ref>PMID:11050006</ref> <ref>PMID:15840691</ref> <ref>PMID:16324104</ref> <ref>PMID:17056143</ref>
-[[Category: Structural Genomics Consortium (Sgc)]]
+== References ==
-[[Category: Zhu, W.F]]
+<references/>
-[[Category: Kraemer, A]]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Hernandez-Olmos V]]
+[[Category: Knapp S]]
+[[Category: Kraemer A]]
+[[Category: Proschak E]]
+[[Category: Zhu WF]]

8bfs: Difference between revisions

Revision as of 20:15, 16 November 2022

Crystal structure of human calmodulin-dependent protein kinase 1D (CAMK1D) in complex with FZ326

Structural highlights

Function

References

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