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==Crystal structure of Weissella viridescens FemXVv non-ribosomal amino acid transferase in complex with a peptidyl-RNA conjugate==
==Crystal structure of Weissella viridescens FemXVv non-ribosomal amino acid transferase in complex with a peptidyl-RNA conjugate==
<StructureSection load='4ii9' size='340' side='right' caption='[[4ii9]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
<StructureSection load='4ii9' size='340' side='right'caption='[[4ii9]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ii9]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/"lactobacillus_viridescens_subsp._minor"_kandler_and_albo-elnaga_1966 "lactobacillus viridescens subsp. minor" kandler and albo-elnaga 1966]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4II9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ii9]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Weissella_viridescens Weissella viridescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4II9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4II9 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MUB:N-ACETYLMURAMIC+ACID'>MUB</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A9Z:2-DEOXY-2-(4-ETHYL-1H-1,2,3-TRIAZOL-1-YL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A9Z</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=FGA:GAMMA-D-GLUTAMIC+ACID'>FGA</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MUB:N-ACETYLMURAMIC+ACID'>MUB</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=A9Z:2-DEOXY-2-(4-ETHYL-1H-1,2,3-TRIAZOL-1-YL)ADENOSINE+5-(DIHYDROGEN+PHOSPHATE)'>A9Z</scene>, <scene name='pdbligand=DAL:D-ALANINE'>DAL</scene>, <scene name='pdbligand=FGA:GAMMA-D-GLUTAMIC+ACID'>FGA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ii9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ii9 OCA], [https://pdbe.org/4ii9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ii9 RCSB], [https://www.ebi.ac.uk/pdbsum/4ii9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ii9 ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1ne9|1ne9]], [[1p4n|1p4n]], [[1xe4|1xe4]], [[1xf8|1xf8]], [[1xix|1xix]], [[3gkr|3gkr]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">femX ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1629 "Lactobacillus viridescens subsp. minor" Kandler and Albo-Elnaga 1966])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UDP-N-acetylmuramoylpentapeptide-lysine_N(6)-alanyltransferase UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.2.10 2.3.2.10] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ii9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ii9 OCA], [http://pdbe.org/4ii9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ii9 RCSB], [http://www.ebi.ac.uk/pdbsum/4ii9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ii9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FEMX_WEIVI FEMX_WEIVI] Involved in the synthesis of the bacterial cell wall. Catalyzes the addition of alanine into the interchain peptide bridge of peptidoglycan precursor using aminoacyl-tRNA(Ala) as amino acid donor. This alanine is added to the epsilon-amino group of the L-lysine of the peptidoglycan UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine, in a ribosome-independent mechanism (PubMed:11083873, PubMed:4248527, PubMed:12679335, PubMed:15901708, PubMed:23744707). Specific for UDP-N-acetyl-muramoyl-pentapeptide. Has no activity toward UDP-N-acetyl-muramoyl-tetrapeptide or UDP-N-acetyl-muramoyl-tripeptide (PubMed:15901708). Also acts on L-seryl-tRNA(Ser) (PubMed:4248527).<ref>PMID:11083873</ref> <ref>PMID:12679335</ref> <ref>PMID:15901708</ref> <ref>PMID:23744707</ref> <ref>PMID:4248527</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lactobacillus viridescens subsp. minor kandler and albo-elnaga 1966]]
[[Category: Large Structures]]
[[Category: Arthur, M]]
[[Category: Weissella viridescens]]
[[Category: Etheve-Quelquejeu, M]]
[[Category: Arthur M]]
[[Category: Fonvielle, M]]
[[Category: Etheve-Quelquejeu M]]
[[Category: Sierra-Gallay, I Li de la]]
[[Category: Fonvielle M]]
[[Category: Tilbeurgh, H van]]
[[Category: Li de la Sierra-Gallay I]]
[[Category: Femx]]
[[Category: Van Tilbeurgh H]]
[[Category: Peptidoglycan]]
[[Category: Peptidyl-rna conjugate complex]]
[[Category: Transferase]]
[[Category: Transferase-peptide-rna complex]]

Revision as of 20:47, 16 November 2022

Crystal structure of Weissella viridescens FemXVv non-ribosomal amino acid transferase in complex with a peptidyl-RNA conjugate

4ii9, resolution 1.66Å

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