4ilg: Difference between revisions

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==Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains==
==Crystal structure of Aar2p in complex with the Prp8p RNaseH and Jab1/MPN domains==
<StructureSection load='4ilg' size='340' side='right' caption='[[4ilg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4ilg' size='340' side='right'caption='[[4ilg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4ilg]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Baker's_yeast Baker's yeast]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ILG FirstGlance]. <br>
<table><tr><td colspan='2'>[[4ilg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ILG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ILG FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ilh|4ilh]], [[4ili|4ili]], [[4ilj|4ilj]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ilg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilg OCA], [https://pdbe.org/4ilg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ilg RCSB], [https://www.ebi.ac.uk/pdbsum/4ilg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilg ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AAR2, YBL074C, YBL06.06, YBL0611 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast]), PRP8, DBF3, DNA39, RNA8, SLT21, USA2, YHR165C ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=559292 Baker's yeast])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ilg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ilg OCA], [http://pdbe.org/4ilg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ilg RCSB], [http://www.ebi.ac.uk/pdbsum/4ilg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ilg ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AAR2_YEAST AAR2_YEAST]] Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth. [[http://www.uniprot.org/uniprot/PRP8_YEAST PRP8_YEAST]] Required for pre-spliceosome formation, which is the first step of pre-mRNA splicing. This protein is associated with snRNP U5. Has a role in branch site-3' splice site selection. Associates with the branch site-3' splice 3'-exon region. Also has a role in cell cycle.<ref>PMID:2835658</ref> <ref>PMID:9150140</ref> <ref>PMID:12773561</ref> <ref>PMID:18779563</ref> 
[https://www.uniprot.org/uniprot/AAR2_YEAST AAR2_YEAST] Involved in splicing pre-mRNA of the A1 cistron and other genes that are important for cell growth.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Pre-mRNA-splicing factor|Pre-mRNA-splicing factor]]
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Baker's yeast]]
[[Category: Large Structures]]
[[Category: Heroven, A C]]
[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Santos, K F]]
[[Category: Heroven AC]]
[[Category: Wahl, M C]]
[[Category: Santos KF]]
[[Category: Weber, G]]
[[Category: Wahl MC]]
[[Category: Aar2]]
[[Category: Weber G]]
[[Category: Prp8]]
[[Category: Splicing]]
[[Category: U5 snrnp assembly]]
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