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==Crystal Structure of Methyionyl-tRNA Formyltransferase from Bacillus anthracis==
==Crystal Structure of Methyionyl-tRNA Formyltransferase from Bacillus anthracis==
<StructureSection load='4iqf' size='340' side='right' caption='[[4iqf]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
<StructureSection load='4iqf' size='340' side='right'caption='[[4iqf]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4iqf]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cereus_var._anthracis"_(cohn_1872)_smith_et_al._1946 "bacillus cereus var. anthracis" (cohn 1872) smith et al. 1946]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rfo 3rfo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQF FirstGlance]. <br>
<table><tr><td colspan='2'>[[4iqf]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=3rfo 3rfo]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQF FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=PG5:1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE'>PG5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PG5:1-METHOXY-2-[2-(2-METHOXY-ETHOXY]-ETHANE'>PG5</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqf OCA], [https://pdbe.org/4iqf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqf RCSB], [https://www.ebi.ac.uk/pdbsum/4iqf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqf ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BAS3717, BA_4004, fmt, GBAA_4004 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1392 "Bacillus cereus var. anthracis" (Cohn 1872) Smith et al. 1946])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Methionyl-tRNA_formyltransferase Methionyl-tRNA formyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.2.9 2.1.2.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqf OCA], [http://pdbe.org/4iqf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iqf RCSB], [http://www.ebi.ac.uk/pdbsum/4iqf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FMT_BACAN FMT_BACAN]] Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.[HAMAP-Rule:MF_00182]  
[https://www.uniprot.org/uniprot/FMT_BACAN FMT_BACAN] Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by: (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP.[HAMAP-Rule:MF_00182]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Methionyl-tRNA formyltransferase]]
[[Category: Bacillus anthracis]]
[[Category: Anderson, W F]]
[[Category: Large Structures]]
[[Category: Structural genomic]]
[[Category: Anderson WF]]
[[Category: Joachimiak, A]]
[[Category: Joachimiak A]]
[[Category: Kim, Y]]
[[Category: Kim Y]]
[[Category: Kwon, K]]
[[Category: Kwon K]]
[[Category: Makowska-Grzyska, M]]
[[Category: Makowska-Grzyska M]]
[[Category: Alpha-beta structure]]
[[Category: Csgid]]
[[Category: National institute of allergy and infectious disease]]
[[Category: Niaid]]
[[Category: Transferase]]
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