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==Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase==
==Mutant P44S P169S M296I of Foot-and-mouth disease Virus RNA-dependent RNA polymerase==
<StructureSection load='4iqx' size='340' side='right' caption='[[4iqx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
<StructureSection load='4iqx' size='340' side='right'caption='[[4iqx]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4iqx]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Aphthovirus_c Aphthovirus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IQX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4iqx]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Foot_and_mouth_disease_virus_C Foot and mouth disease virus C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IQX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4IQX FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3nl0|3nl0]], [[3nky|3nky]], [[3nma|3nma]]</td></tr>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4iqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqx OCA], [https://pdbe.org/4iqx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4iqx RCSB], [https://www.ebi.ac.uk/pdbsum/4iqx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqx ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">3D ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=12116 Aphthovirus C])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4iqx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4iqx OCA], [http://pdbe.org/4iqx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4iqx RCSB], [http://www.ebi.ac.uk/pdbsum/4iqx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4iqx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO]] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]  
[https://www.uniprot.org/uniprot/Q9QCE4_9PICO Q9QCE4_9PICO] Protein 3C is a cysteine protease that generates mature viral proteins from the precursor polyprotein. In addition to its proteolytic activity, it binds to viral RNA, and thus influences viral genome replication. RNA and substrate bind co-operatively to the protease (By similarity).[SAAS:SAAS000199_004_042266]  RNA-directed RNA polymerase 3D-POL replicates genomic and antigenomic RNA by recognizing replications specific signals (By similarity).[SAAS:SAAS000199_004_010047]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[RNA polymerase|RNA polymerase]]
*[[RNA polymerase 3D structures|RNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Aphthovirus c]]
[[Category: Foot and mouth disease virus C]]
[[Category: Agudo, R]]
[[Category: Large Structures]]
[[Category: Ferrer-Orta, C]]
[[Category: Synthetic construct]]
[[Category: Perez-Luque, R]]
[[Category: Agudo R]]
[[Category: Verdaguer, N]]
[[Category: Ferrer-Orta C]]
[[Category: 3d polymerase]]
[[Category: Perez-Luque R]]
[[Category: Close right hand conformation]]
[[Category: Verdaguer N]]
[[Category: Rna-dependent rna polymerase]]
[[Category: Transferase-dna complex]]
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