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==Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1==
==Crystal Structure of the inactive Matriptase in complex with its inhibitor HAI-1==
<StructureSection load='4isl' size='340' side='right' caption='[[4isl]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='4isl' size='340' side='right'caption='[[4isl]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4isl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ISL FirstGlance]. <br>
<table><tr><td colspan='2'>[[4isl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ISL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ISL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4is5|4is5]], [[4isn|4isn]], [[4iso|4iso]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4isl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isl OCA], [https://pdbe.org/4isl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4isl RCSB], [https://www.ebi.ac.uk/pdbsum/4isl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4isl ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HAI1, SPINT1, UNQ223/PRO256 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), PRSS14, SNC19, ST14, TADG15 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Matriptase Matriptase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.109 3.4.21.109] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4isl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4isl OCA], [http://pdbe.org/4isl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4isl RCSB], [http://www.ebi.ac.uk/pdbsum/4isl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4isl ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Defects in ST14 are a cause of ichthyosis autosomal recessive with hypotrichosis (ARIH) [MIM:[http://omim.org/entry/610765 610765]]. ARIH is a skin disorder characterized by congenital ichthyosis associated with the presence of less than the normal amount of hair.<ref>PMID:17273967</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/SPIT1_HUMAN SPIT1_HUMAN]] Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14). [[http://www.uniprot.org/uniprot/ST14_HUMAN ST14_HUMAN]] Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site.  
[https://www.uniprot.org/uniprot/SPIT1_HUMAN SPIT1_HUMAN] Inhibitor of HGF activator. Also acts as an inhibitor of matriptase (ST14).
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4isl" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4isl" style="background-color:#fffaf0;"></div>
==See Also==
*[[Hepatocyte growth factor activator inhibitor|Hepatocyte growth factor activator inhibitor]]
*[[Matriptase 3D structures|Matriptase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Matriptase]]
[[Category: Large Structures]]
[[Category: Huang, M D]]
[[Category: Huang MD]]
[[Category: Li, R]]
[[Category: Li R]]
[[Category: Yuan, C]]
[[Category: Yuan C]]
[[Category: Zhao, B Y]]
[[Category: Zhao BY]]
[[Category: Beta barrel]]
[[Category: Epithelium]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Serine protease inhibitor]]
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