7fqt: Difference between revisions

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'''Unreleased structure'''


The entry 7fqt is ON HOLD
==PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with FMOMB000293a==
 
<StructureSection load='7fqt' size='340' side='right'caption='[[7fqt]], [[Resolution|resolution]] 2.54&Aring;' scene=''>
Authors: Mehlman, T., Biel, J., Azeem, S.M., Nelson, E.R., Hossain, S., Dunnett, L.E., Paterson, N.G., Douangamath, A., Talon, R., Axford, D., Orins, H., von Delft, F., Keedy, D.A.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7fqt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FQT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FQT FirstGlance]. <br>
Description: PanDDA analysis group deposition --Crystal structure of PTP1B in complex with FMOMB000293a
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JJY:3,4,6,7-tetrahydroacridine-1,8(2H,5H)-dione'>JJY</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fqt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fqt OCA], [https://pdbe.org/7fqt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fqt RCSB], [https://www.ebi.ac.uk/pdbsum/7fqt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fqt ProSAT]</span></td></tr>
[[Category: Mehlman, T]]
</table>
[[Category: Biel, J]]
== Function ==
[[Category: Nelson, E.R]]
[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
[[Category: Azeem, S.M]]
== References ==
[[Category: Paterson, N.G]]
<references/>
[[Category: Dunnett, L.E]]
__TOC__
[[Category: Talon, R]]
</StructureSection>
[[Category: Keedy, D.A]]
[[Category: Homo sapiens]]
[[Category: Douangamath, A]]
[[Category: Large Structures]]
[[Category: Hossain, S]]
[[Category: Axford D]]
[[Category: Orins, H]]
[[Category: Azeem SM]]
[[Category: Von Delft, F]]
[[Category: Biel J]]
[[Category: Axford, D]]
[[Category: Douangamath A]]
[[Category: Dunnett LE]]
[[Category: Hossain S]]
[[Category: Keedy DA]]
[[Category: Mehlman T]]
[[Category: Nelson ER]]
[[Category: Orins H]]
[[Category: Paterson NG]]
[[Category: Talon R]]
[[Category: Von Delft F]]
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