8ba5: Difference between revisions
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==Crystal structure of the DNMT3A ADD domain== | |||
<StructureSection load='8ba5' size='340' side='right'caption='[[8ba5]], [[Resolution|resolution]] 1.45Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8ba5]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8BA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8BA5 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ba5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ba5 OCA], [https://pdbe.org/8ba5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ba5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ba5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ba5 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/DNM3A_HUMAN DNM3A_HUMAN] Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. It modifies DNA in a non-processive manner and also methylates non-CpG sites. May preferentially methylate DNA linker between 2 nucleosomal cores and is inhibited by histone H1. Plays a role in paternal and maternal imprinting. Required for methylation of most imprinted loci in germ cells. Acts as a transcriptional corepressor for ZNF238. Can actively repress transcription through the recruitment of HDAC activity (By similarity).<ref>PMID:16357870</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Broehm A]] | |||
[[Category: Jeltsch A]] | |||
[[Category: Kunert S]] | |||
[[Category: Linhard V]] | |||
[[Category: Schwalbe H]] | |||
[[Category: Wollenhaupt J]] | |||
Revision as of 10:14, 24 November 2022
Crystal structure of the DNMT3A ADD domain
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