7ul2: Difference between revisions

Line 1:

==CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6==

== Structural highlights ==

<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7UL2 FirstGlance].

<table><tr><td colspan='2'>[[7ul2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL2 OCA]. For a guided tour on the structure components use [https://proteopedia.org/fgij/fg.htm?mol=7UL2 FirstGlance].

</td></tr><tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul2 OCA], [https://pdbe.org/7ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul2 ProSAT]</td></tr>

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q6Q:2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic+acid'>Q6Q</scene></td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[https://proteopedia.org/fgij/fg.htm?mol=7ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul2 OCA], [https://pdbe.org/7ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul2 ProSAT]</td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> [https://www.uniprot.org/uniprot/NTR1_HUMAN NTR1_HUMAN] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Lama glama]]

[[Category: Large Structures]]

[[Category: Robertson, MJ, Skiniotis, G]]

[[Category: Robertson MJ]]

[[Category: Skiniotis G]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
 ==CryoEM Structure of Inactive NTSR1 Bound to SR48692 and Nb6==
-<StructureSection load='7ul2' size='340' side='right'caption='[[7ul2]]' scene=''>
+<StructureSection load='7ul2' size='340' side='right'caption='[[7ul2]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL2 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[7ul2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Lama_glama Lama glama]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UL2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UL2 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul2 OCA], [https://pdbe.org/7ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul2 ProSAT]</span></td></tr>
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=Q6Q:2-[[1-(7-chloranylquinolin-4-yl)-5-(2,6-dimethoxyphenyl)pyrazol-3-yl]carbonylamino]adamantane-2-carboxylic+acid'>Q6Q</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ul2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ul2 OCA], [https://pdbe.org/7ul2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ul2 RCSB], [https://www.ebi.ac.uk/pdbsum/7ul2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ul2 ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/OPRK_HUMAN OPRK_HUMAN] G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.<ref>PMID:12004055</ref> <ref>PMID:22437504</ref> <ref>PMID:7624359</ref> <ref>PMID:8060324</ref> [https://www.uniprot.org/uniprot/NTR1_HUMAN NTR1_HUMAN] Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
+== References ==
+<references/>
 __TOC__
 </StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Lama glama]]
 [[Category: Large Structures]]
-[[Category: Robertson, MJ, Skiniotis, G]]
+[[Category: Robertson MJ]]
+[[Category: Skiniotis G]]