4jmx: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:


==Structure of LD transpeptidase LdtMt1 in complex with imipenem==
==Structure of LD transpeptidase LdtMt1 in complex with imipenem==
<StructureSection load='4jmx' size='340' side='right' caption='[[4jmx]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
<StructureSection load='4jmx' size='340' side='right'caption='[[4jmx]], [[Resolution|resolution]] 2.55&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jmx]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JMX FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jmx]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JMX FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IM2:(5R)-5-[(1S,2R)-1-FORMYL-2-HYDROXYPROPYL]-3-[(2-{[(E)-IMINOMETHYL]AMINO}ETHYL)SULFANYL]-4,5-DIHYDRO-1H-PYRROLE-2-CARBOXYLIC+ACID'>IM2</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jmn|4jmn]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmx OCA], [https://pdbe.org/4jmx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jmx RCSB], [https://www.ebi.ac.uk/pdbsum/4jmx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmx ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ldtA, Rv0116c ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 "Bacillus tuberculosis" (Zopf 1883) Klein 1884])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jmx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jmx OCA], [http://pdbe.org/4jmx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jmx RCSB], [http://www.ebi.ac.uk/pdbsum/4jmx PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jmx ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/LDT1_MYCTU LDT1_MYCTU] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems. Is thought to play a role in adaptation to the nonreplicative state of M.tuberculosis.<ref>PMID:18408028</ref> <ref>PMID:24041897</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 22: Line 22:
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Berisio, R]]
[[Category: Large Structures]]
[[Category: Capparelli, R]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Correale, S]]
[[Category: Berisio R]]
[[Category: Pedone, E]]
[[Category: Capparelli R]]
[[Category: Ruggiero, A]]
[[Category: Correale S]]
[[Category: Ig-like and beta barrel]]
[[Category: Pedone E]]
[[Category: Transferase]]
[[Category: Ruggiero A]]
[[Category: Transferase-transferase inhibitor complex]]

Revision as of 11:24, 24 November 2022

Structure of LD transpeptidase LdtMt1 in complex with imipenem

4jmx, resolution 2.55Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=4jmx&oldid=3671335"