4jnm: Difference between revisions
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==Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties== | ==Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties== | ||
<StructureSection load='4jnm' size='340' side='right' caption='[[4jnm]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4jnm' size='340' side='right'caption='[[4jnm]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4jnm]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4jnm]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JNM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JNM FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1LJ:1-[(6-AMINOPYRIDIN-3-YL)METHYL]-3-[4-(PHENYLSULFONYL)PHENYL]UREA'>1LJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1LJ:1-[(6-AMINOPYRIDIN-3-YL)METHYL]-3-[4-(PHENYLSULFONYL)PHENYL]UREA'>1LJ</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jnm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jnm OCA], [https://pdbe.org/4jnm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jnm RCSB], [https://www.ebi.ac.uk/pdbsum/4jnm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jnm ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/NAMPT_HUMAN NAMPT_HUMAN] Catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, an intermediate in the biosynthesis of NAD. It is the rate limiting component in the mammalian NAD biosynthesis pathway (By similarity). | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Phosphoribosyltransferase|Phosphoribosyltransferase]] | *[[Phosphoribosyltransferase 3D structures|Phosphoribosyltransferase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Bair | [[Category: Bair KW]] | ||
[[Category: Bauer | [[Category: Bauer P]] | ||
[[Category: Baumeister | [[Category: Baumeister T]] | ||
[[Category: Buckmelter AJ]] | |||
[[Category: Buckmelter | [[Category: Caligiuri M]] | ||
[[Category: Caligiuri | [[Category: Clodfelter KH]] | ||
[[Category: Clodfelter | [[Category: Dragovich PS]] | ||
[[Category: Dragovich | [[Category: Fu B]] | ||
[[Category: Fu | [[Category: Gunzner-Toste J]] | ||
[[Category: Gunzner-Toste | [[Category: Han B]] | ||
[[Category: Han | [[Category: Ho Y]] | ||
[[Category: Ho | [[Category: Kley N]] | ||
[[Category: Kley | [[Category: Liederer B]] | ||
[[Category: Liederer | [[Category: Lin J]] | ||
[[Category: Lin | [[Category: Mukadam S]] | ||
[[Category: Mukadam | [[Category: O'Brien T]] | ||
[[Category: Oh | [[Category: Oh A]] | ||
[[Category: Reynolds | [[Category: Reynolds DJ]] | ||
[[Category: Sharma | [[Category: Sharma G]] | ||
[[Category: Skelton | [[Category: Skelton N]] | ||
[[Category: Smith | [[Category: Smith CC]] | ||
[[Category: Wang | [[Category: Wang W]] | ||
[[Category: Wang | [[Category: Wang Z]] | ||
[[Category: Xiao | [[Category: Xiao Y]] | ||
[[Category: Yuen | [[Category: Yuen P]] | ||
[[Category: Zak | [[Category: Zak M]] | ||
[[Category: Zhang | [[Category: Zhang L]] | ||
[[Category: Zhao | [[Category: Zhao G]] | ||
[[Category: Zheng | [[Category: Zheng X]] | ||
Revision as of 11:25, 24 November 2022
Discovery of Potent and Efficacious Urea-containing Nicotinamide Phosphoribosyltransferase (NAMPT) Inhibitors with Reduced CYP2C9 Inhibition Properties
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