Androgen receptor: Difference between revisions
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===Ligand-Independent actions of the AR=== | ===Ligand-Independent actions of the AR=== | ||
It has been demonstrated that AR has the potential to be activated through ligand-independent mechanisms by a number of different growth factors, via phosphorylation of the AR or following interaction with co-activators <ref name="Bench to Bedside" />. | It has been demonstrated that AR has the potential to be activated through ligand-independent mechanisms by a number of different growth factors, via phosphorylation of the AR or following interaction with co-activators <ref name="Bench to Bedside" />. | ||
=Function= | =Function= | ||
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Androgen depletion is considered a significant risk factor for Alzheimer’s disease and circulating testosterone levels are inversely correlated with levels of ß-amyloid (ßA) in the brains of aged men <ref name="SARMs knowledge" />. | Androgen depletion is considered a significant risk factor for Alzheimer’s disease and circulating testosterone levels are inversely correlated with levels of ß-amyloid (ßA) in the brains of aged men <ref name="SARMs knowledge" />. | ||
=Pharmacology= | |||
=Pharmacology <span class="fas fa-capsules"></span>= | |||
==Steroid== | ==Steroid== | ||
===Natural ligand: Testosterone=== | ===Natural ligand: Testosterone=== | ||
