Androgen receptor: Difference between revisions

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==Transcriptional Activation Function==

Two transcriptional activation functions have been identified:

*The ligand-independent AF-1 (residues 142-485): located in the NTD is constitutively active. It is the main region responsible for mediating AR transcription. ~~This region~~ contains two separable transcription activation units that are indispensable for full activity of the AR <ref name="Structure" />.

*The ligand-independent AF-1 (residues 142-485): located in the NTD is constitutively active. It is the main region responsible for mediating AR transcription. Its contains two separable transcription activation units that are indispensable for full activity of the AR <ref name="Structure" />.

*The ligand-dependent AF-2: is located in the ~~ligand binding domain~~ <ref name="Bench to Bedside" />. <scene name='54/543362/H12_androgen_receptor/1'>H12</scene> forms the core of this region and acts as a lid to close the LBP upon agonist binding <ref name="Structure" />. It is important for forming the coregulator bindings site as well as mediating direct interactions between the N-terminal and ligand binding domains. Key differences in the contribution of specific conserved residues in the AF-2 core domain between the AR and other steroid hormone nuclear receptors have been identified, it would explain the differences in the structure and the function, as well as the coregulatory proteins they interact with <ref name="Bench to Bedside" />.

*The ligand-dependent AF-2: is located in the LBD <ref name="Bench to Bedside" />. <scene name='54/543362/H12_androgen_receptor/1'>Helix 12 (H12)</scene> forms the core of this region and acts as a lid to close the LBP upon agonist binding <ref name="Structure" />. It is important for forming the coregulator bindings site as well as mediating direct interactions between the N-terminal and ligand binding domains. Key differences in the contribution of specific conserved residues in the AF-2 core domain between the AR and other steroid hormone nuclear receptors have been identified, it would explain the differences in the structure and the function, as well as the coregulatory proteins they interact with <ref name="Bench to Bedside" />.

Androgen receptor: Difference between revisions

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@@ Line 26: / Line 26: @@
 ==Transcriptional Activation Function==
 Two transcriptional activation functions have been identified:
-*The ligand-independent AF-1 (residues 142-485): located in the NTD is constitutively active. It is the main region responsible for mediating AR transcription. This region contains two separable transcription activation units that are indispensable for full activity of the AR <ref name="Structure" />.
+*The ligand-independent AF-1 (residues 142-485): located in the NTD is constitutively active. It is the main region responsible for mediating AR transcription. Its contains two separable transcription activation units that are indispensable for full activity of the AR <ref name="Structure" />.
-*The ligand-dependent AF-2: is located in the ligand binding domain <ref name="Bench to Bedside" />. <scene name='54/543362/H12_androgen_receptor/1'>H12</scene> forms the core of this region and acts as a lid to close the LBP upon agonist binding <ref name="Structure" />. It is important for forming the coregulator bindings site as well as mediating direct interactions between the N-terminal and ligand binding domains. Key differences in the contribution of specific conserved residues in the AF-2 core domain between the AR and other steroid hormone nuclear receptors have been identified, it would explain the differences in the structure and the function, as well as the coregulatory proteins they interact with <ref name="Bench to Bedside" />.
+*The ligand-dependent AF-2: is located in the LBD <ref name="Bench to Bedside" />. <scene name='54/543362/H12_androgen_receptor/1'>Helix 12 (H12)</scene> forms the core of this region and acts as a lid to close the LBP upon agonist binding <ref name="Structure" />. It is important for forming the coregulator bindings site as well as mediating direct interactions between the N-terminal and ligand binding domains. Key differences in the contribution of specific conserved residues in the AF-2 core domain between the AR and other steroid hormone nuclear receptors have been identified, it would explain the differences in the structure and the function, as well as the coregulatory proteins they interact with <ref name="Bench to Bedside" />.