Sandbox Reserved 1732: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Mary Lively (talk | contribs) Undo revision 3671946 by Mary Lively (Talk) |
Mary Lively (talk | contribs) No edit summary |
||
| Line 25: | Line 25: | ||
== Structural highlights == | == Structural highlights == | ||
An insulin receptor is a dimer of heterodimers. The dimers are noncovalent, but the insulin receptors are covalently maintained as functional dimers by disulfide bonds. An insulin receptor is comprised of 2 α-chains, and 2 β-chains. The α-chain and an estimated 190 residues of the β-chain are located on the extracellular side of the plasma membrane. The rest of the beta-chain consists of a single transmembrane helix, the juxtamembrane domain, and the intracellular tyrosine kinase domain. | An insulin receptor is a dimer of heterodimers. The dimers are noncovalent, but the insulin receptors are covalently maintained as functional dimers by disulfide bonds. An insulin receptor is comprised of 2 α-chains, and 2 β-chains. The α-chain and an estimated 190 residues of the β-chain are located on the extracellular side of the plasma membrane. The rest of the beta-chain consists of a single transmembrane helix, the juxtamembrane domain, and the intracellular tyrosine kinase domain. | ||
The alpha subunits are the site for insulin binding. Each subunit is comprised of 2 Leucine rich domains (L1 and L2), a Cysteine rich domain (CR) and an α-chain C-terminal helix (α-CT). The two subunits are held together by a disulfide bond between the cysteine rich domains.<ref>http://biorxiv.org/</ref> | The alpha subunits are the site for insulin binding. Each subunit is comprised of 2 Leucine rich domains (L1 and L2), a Cysteine rich domain (CR) and an α-chain C-terminal helix (α-CT). The two subunits are held together by a disulfide bond between the cysteine rich domains. Site L1' is dark green, CR' is orange, L2' is light blue, L2 is yellow, CR is red, L1 is dark blue, β-subunits are brown and light pink, insulin bound to the receptor is hot pink.<ref>http://biorxiv.org/</ref> | ||
[[Image:6CE7.png]] | [[Image:6CE7.png]] | ||
