Sandbox Reserved 1732: Difference between revisions
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[[Image:6CE7.png]] | [[Image:6CE7.png]] | ||
Due to the heterodimeric nature of the receptor, there are two types of insulin binding sites that are split into pairs in the alpha subunits: sites 1 and 1' and sites 2 and 2', for a total of 4 binding sites of insulin. Binding sites 1 and 1' have a greater surface area and are more easily accessible for the insulin to bond, resulting in a higher affinity for insulin binding. Binding sites 2 and 2' have less surface area and are located on the back of the beta sheet so their binding sites do not get filled as quickly.The beta subunits consist of Fibronectin domain III-2 (FnIII-2) and Fibronectin domain III-3 (FnIII-3). | Due to the heterodimeric nature of the receptor, there are two types of insulin binding sites that are split into pairs in the alpha subunits: sites 1 and 1' and sites 2 and 2', for a total of 4 binding sites of insulin. Binding sites 1 and 1' have a greater surface area and are more easily accessible for the insulin to bond, resulting in a higher affinity for insulin binding. Binding sites 2 and 2' have less surface area and are located on the back of the beta sheet so their binding sites do not get filled as quickly.The beta subunits consist of Fibronectin domain III-2 (FnIII-2) and Fibronectin domain III-3 (FnIII-3). In the image below, Sites 1 and 1' are green. Sites 2 and 2' are red. | ||
[[Image:biochemIBSpt2.png]] | [[Image:biochemIBSpt2.png]] | ||
