7qbq: Difference between revisions

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'''Unreleased structure'''


The entry 7qbq is ON HOLD  until Paper Publication
==Human butyrylcholinesterase in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide==
 
<StructureSection load='7qbq' size='340' side='right'caption='[[7qbq]], [[Resolution|resolution]] 2.49&Aring;' scene=''>
Authors: Denic, M., Chioua, M., Knez, D., Gobec, S., Nachon, F., Marco-Contelles, J.L., Brazzolotto, X.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[7qbq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QBQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QBQ FirstGlance]. <br>
Description: Human butyrylcholinesterase in complex with (Z)-N-benzyl-1-(8-hydroxyquinolin-2-yl)methanimine oxide
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AI0:1-(8-oxidanylquinolin-2-yl)-N-(phenylmethyl)methanimine+oxide'>AI0</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qbq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qbq OCA], [https://pdbe.org/7qbq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qbq RCSB], [https://www.ebi.ac.uk/pdbsum/7qbq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qbq ProSAT]</span></td></tr>
[[Category: Brazzolotto, X]]
</table>
[[Category: Gobec, S]]
== Disease ==
[[Category: Knez, D]]
[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Defects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:[https://omim.org/entry/177400 177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
[[Category: Nachon, F]]
== Function ==
[[Category: Chioua, M]]
[https://www.uniprot.org/uniprot/CHLE_HUMAN CHLE_HUMAN] Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.<ref>PMID:19542320</ref> <ref>PMID:19452557</ref>
[[Category: Marco-Contelles, J.L]]
== References ==
[[Category: Denic, M]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Brazzolotto X]]
[[Category: Chioua M]]
[[Category: Denic M]]
[[Category: Gobec S]]
[[Category: Knez D]]
[[Category: Marco-Contelles JL]]
[[Category: Nachon F]]
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