8dvp: Difference between revisions

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'''Unreleased structure'''


The entry 8dvp is ON HOLD  until Paper Publication
==Glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with substrate purine==
 
<StructureSection load='8dvp' size='340' side='right'caption='[[8dvp]], [[Resolution|resolution]] 1.54&Aring;' scene=''>
Authors: Demir, M., Russelburg, L.P., Horvath, M.P., David, S.S.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8dvp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacillus_stearothermophilus Geobacillus stearothermophilus] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8DVP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8DVP FirstGlance]. <br>
Description: Glycosylase MutY variant N146S in complex with DNA containing d(8-oxo-G) paired with substrate purine
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=8OG:8-OXO-2-DEOXY-GUANOSINE-5-MONOPHOSPHATE'>8OG</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PRN:PURINE+2-DEOXYRIBO-5-MONOPHOSPHATE'>PRN</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8dvp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8dvp OCA], [https://pdbe.org/8dvp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8dvp RCSB], [https://www.ebi.ac.uk/pdbsum/8dvp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8dvp ProSAT]</span></td></tr>
[[Category: Horvath, M.P]]
</table>
[[Category: Demir, M]]
== Function ==
[[Category: David, S.S]]
[https://www.uniprot.org/uniprot/MUTY_GEOSE MUTY_GEOSE] Base excision repair (BER) glycosylase that initiates repair of A:oxoG to C:G by removing the inappropriately paired adenine base from the DNA backbone, generating an abasic site product (PubMed:25995449) (PubMed:14961129). 8-oxoguanine (oxoG) is a genotoxic DNA lesion resulting from oxidation of guanine; this residue is misread by replicative DNA polymerases, that insert adenine instead of cytosine opposite the oxidized damaged base. Shows a powerful dicrimination of A versus C, since it does not cleave cytosine in oxoG:C pairs (PubMed:25995449). May also be able to remove adenine from A:G mispairs, although this activity may not be physiologically relevant (PubMed:14961129).<ref>PMID:25995449</ref> <ref>PMID:14961129</ref>
[[Category: Russelburg, L.P]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Geobacillus stearothermophilus]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: David SS]]
[[Category: Demir M]]
[[Category: Horvath MP]]
[[Category: Russelburg LP]]
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