8e1v: Difference between revisions

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'''Unreleased structure'''


The entry 8e1v is ON HOLD  until Paper Publication
==Asp1 kinase in complex with ADPNP Mg IP6==
 
<StructureSection load='8e1v' size='340' side='right'caption='[[8e1v]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
Authors: Goldgur, Y., Shuman, S., Benjamin, B.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8e1v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Schizosaccharomyces_pombe Schizosaccharomyces pombe]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8E1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8E1V FirstGlance]. <br>
Description: Asp1 kinase in complex with ADPNP Mg IP6
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8e1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8e1v OCA], [https://pdbe.org/8e1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8e1v RCSB], [https://www.ebi.ac.uk/pdbsum/8e1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8e1v ProSAT]</span></td></tr>
[[Category: Benjamin, B]]
</table>
[[Category: Goldgur, Y]]
== Function ==
[[Category: Shuman, S]]
[https://www.uniprot.org/uniprot/VIP1_SCHPO VIP1_SCHPO] Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. Phosphorylates inositol hexakisphosphate (InsP6) at position 1 to produce PP-InsP5 which is in turn phosphorylated by IP6Ks to produce (PP)2-InsP4. Alternatively, phosphorylates PP-InsP5 at position 1, produced by IP6Ks from InsP6, to produce (PP)2-InsP4 (By similarity). Required for maintaining cellular integrity, normal growth and interactions with the ARP complex (PubMed:10388810). Acts as a regulator of the PHO80-PHO85 cyclin/cyclin-dependent kinase (CDK) complex, thereby regulating signaling of phosphate availability (By similarity). Required for the function of the cortical actin cytoskeleton, possibly by participating in correct F-actin localization and ensuring polarized growth (PubMed:10388810). Regulates polarized growth and modulates interphase microtubule cytoskeleton. Regulates microtubule dynamics without the requirement of microtubule plus-end tracking protein Mal3. Required for growth zone selection (PubMed:25254656).[UniProtKB:O43314][UniProtKB:Q06685]<ref>PMID:10388810</ref> <ref>PMID:25254656</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Schizosaccharomyces pombe]]
[[Category: Benjamin B]]
[[Category: Goldgur Y]]
[[Category: Shuman S]]
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