8ea0: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The~~ entry ~~8ea0~~ is ~~ON HOLD until Paper Publication~~

==CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8ea0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EA0 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ea0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ea0 OCA], [https://pdbe.org/8ea0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ea0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ea0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ea0 ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>

== Function ==

[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fay JF]]

[[Category: Roth BL]]

[[Category: Zhang S]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8ea0 is ON HOLD  until Paper Publication
+==CryoEM structure of miniGq-coupled hM3R in complex with iperoxo (local refinement)==
+<StructureSection load='8ea0' size='340' side='right'caption='[[8ea0]], [[Resolution|resolution]] 2.56&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8ea0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EA0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EA0 FirstGlance]. <br>
-Description:
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IXO:4-(4,5-DIHYDRO-1,2-OXAZOL-3-YLOXY)-N,N,N-TRIMETHYLBUT-2-YN-1-AMINIUM'>IXO</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ea0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ea0 OCA], [https://pdbe.org/8ea0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ea0 RCSB], [https://www.ebi.ac.uk/pdbsum/8ea0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ea0 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] Defects in CHRM3 are the cause of Eagle-Barrett syndrome (EGBRS) [MIM:[https://omim.org/entry/100100 100100]. EGBRS is a syndrome characterized by thin abdominal musculature with overlying lax skin, cryptorchism, megacystis with disorganized detrusor muscle, and urinary tract abnormalities.<ref>PMID:22077972</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/ACM3_HUMAN ACM3_HUMAN] The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fay JF]]
+[[Category: Roth BL]]
+[[Category: Zhang S]]