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==Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AEA16==
==Crystal Structure of E.coli Enoyl Reductase in Complex with NAD and AEA16==
<StructureSection load='4jx8' size='340' side='right' caption='[[4jx8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
<StructureSection load='4jx8' size='340' side='right'caption='[[4jx8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4jx8]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JX8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4JX8 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4jx8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4JX8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4JX8 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AE6:6-{(1E)-3-[3-(3-METHYL-1-BENZOFURAN-2-YL)AZETIDIN-1-YL]-3-OXOPROP-1-EN-1-YL}-1,8-NAPHTHYRIDIN-2(1H)-ONE'>AE6</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AE6:6-{(1E)-3-[3-(3-METHYL-1-BENZOFURAN-2-YL)AZETIDIN-1-YL]-3-OXOPROP-1-EN-1-YL}-1,8-NAPHTHYRIDIN-2(1H)-ONE'>AE6</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jqc|4jqc]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4jx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jx8 OCA], [https://pdbe.org/4jx8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4jx8 RCSB], [https://www.ebi.ac.uk/pdbsum/4jx8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4jx8 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">fabI, envM, b1288, JW1281 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Enoyl-[acyl-carrier-protein]_reductase_(NADH) Enoyl-[acyl-carrier-protein] reductase (NADH)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.1.9 1.3.1.9] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jx8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jx8 OCA], [http://pdbe.org/4jx8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jx8 RCSB], [http://www.ebi.ac.uk/pdbsum/4jx8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jx8 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI]] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>
[https://www.uniprot.org/uniprot/FABI_ECOLI FABI_ECOLI] Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP). Involved in the elongation cycle of fatty acid which are used in the lipid metabolism and in the biotin biosynthesis.<ref>PMID:8119879</ref> <ref>PMID:7592873</ref> <ref>PMID:20693992</ref>  


==See Also==
==See Also==
*[[Enoyl-Acyl-Carrier Protein Reductase|Enoyl-Acyl-Carrier Protein Reductase]]
*[[Enoyl-Acyl-Carrier Protein Reductase 3D structures|Enoyl-Acyl-Carrier Protein Reductase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Anirudha, L]]
[[Category: Large Structures]]
[[Category: Rao, K N]]
[[Category: Anirudha L]]
[[Category: Subramanya, H]]
[[Category: Rao KN]]
[[Category: Enoyl reductase]]
[[Category: Subramanya H]]
[[Category: Fabi]]
[[Category: Ligand aea16]]
[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]
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