4k2f: Difference between revisions

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<StructureSection load='4k2f' size='340' side='right'caption='[[4k2f]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
<StructureSection load='4k2f' size='340' side='right'caption='[[4k2f]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4k2f]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4K2F FirstGlance]. <br>
<table><tr><td colspan='2'>[[4k2f]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4K2F OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4K2F FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A08:(2S)-(4-CHLOROPHENYL)(6-CHLOROPYRIDIN-2-YL)ETHANENITRILE'>A08</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A08:(2S)-(4-CHLOROPHENYL)(6-CHLOROPYRIDIN-2-YL)ETHANENITRILE'>A08</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3sra|3sra]], [[3srb|3srb]], [[3src|3src]], [[4k2g|4k2g]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4k2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2f OCA], [https://pdbe.org/4k2f PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4k2f RCSB], [https://www.ebi.ac.uk/pdbsum/4k2f PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2f ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">pvdQ, qsc112, PA2385 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acyl-homoserine-lactone_acylase Acyl-homoserine-lactone acylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.97 3.5.1.97] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4k2f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4k2f OCA], [http://pdbe.org/4k2f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4k2f RCSB], [http://www.ebi.ac.uk/pdbsum/4k2f PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4k2f ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE]] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>
[https://www.uniprot.org/uniprot/PVDQ_PSEAE PVDQ_PSEAE] Catalyzes the deacylation of acyl-homoserine lactone (AHL or acyl-HSL), releasing homoserine lactone (HSL) and the corresponding fatty acid. Possesses a specificity for the degradation of long-chain acyl-HSLs (side chains of 11 to 14 carbons in length). Degrades 3-oxo-C12-HSL, one of the two main AHL signal molecules of P.aeruginosa, and thereby functions as a quorum quencher, inhibiting the las quorum-sensing system. Therefore, may enable P.aeruginosa to modulate its own quorum-sensing-dependent pathogenic potential. Also appears to be required for pyoverdin biosynthesis.<ref>PMID:16495538</ref> <ref>PMID:14532048</ref> <ref>PMID:12686626</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Acyl-homoserine-lactone acylase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Pseae]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Drake, E J]]
[[Category: Drake EJ]]
[[Category: Gulick, A M]]
[[Category: Gulick AM]]
[[Category: Munoz, B]]
[[Category: Munoz B]]
[[Category: Theriault, J R]]
[[Category: Theriault JR]]
[[Category: Wurst, J M]]
[[Category: Wurst JM]]
[[Category: Amidohydrolase]]
[[Category: Bacterial protein]]
[[Category: Catalytic domain]]
[[Category: High-throughput screening assay]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Molecular sequence data]]
[[Category: Oligopeptide]]
[[Category: Small molecule library]]
[[Category: Structure-activity relationship]]
Retrieved from "https://proteopedia.org/4k2f"