Biosynthesis of cholesterol: Difference between revisions
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*[[Mevalonate kinase]] | *[[Mevalonate kinase]] | ||
<scene name='92/929923/Cv/3'>mevalonate</scene> => <scene name='92/929923/Cv/6'>mevalonate-5-phosphate</scene> | |||
The 3D structure of MK complex with mevalonate shows the enzyme composed of <scene name='86/864102/Cv/2'>2 domains</scene>: The N-terminal and the C-terminal. The mevalonate binds in a <scene name='86/864102/Cv/7'>deep cleft</scene> between the 2 domains forming <scene name='86/864102/Cv/6'>H-bonds and hydrophobic interactions</scene><ref>PMID:17397541</ref>. Water molecules are shown as red spheres. | |||
''Phosphomevalonate kinase'' | ''Phosphomevalonate kinase'' | ||
