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| </StructureSection> | | </StructureSection> |
| ==3D structures of cytochrome bc1== | | ==3D structures of cytochrome bc1== |
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| [[Cytochrome bc1 3D structures]] | | [[Cytochrome bc1 3D structures]] |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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| [[1bgy]], [[1be3]], [[1l0n]], [[1ntm]] - bCb + bCc1 + RISP – bovine <BR />
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| [[1qcr]] - bCb + bCc1 + RISP – Cα model<BR />
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| [[1sqp]], [[2fyu]], [[1l0l]], [[1ntk]], [[1pp9]], [[1ppj]], [[1sqb]], [[2a06]], [[1sqv]], [[1sqx]], [[1sqq]] - bCb + bCc1 + RISP + inhibitor<BR />
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| [[4d6u]] - bCb + bCc1 + RISP + antimalarial pyridone<BR />
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| [[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />
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| [[1nu1]], [[6xvf]] - bCb + bCc1 + RISP + quinolone derivative<BR />
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| [[6nhg]] - bCb in respiratory complex <BR />
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| [[6fo2]] - bCb in respiratory complex – Cryo EM<BR />
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| [[6haw]], [[6zfs]], [[6zft]], [[6zfu]] - bCb in respiratory complex + antimalarial inhibitor<BR />
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| [[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />
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| [[7o37]], [[7o3c]], [[7o3e]], [[7o3h]] - Cb in CICIII2 complex – mouse - Cryo EM<BR />
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| [[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
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| [[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
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| [[7jrg]], [[7jrp]] - Cb in III2 complex – bean - Cryo EM <BR />
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| [[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />
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| [[3cx5]] - yCb + yCc1 + RISP <BR />
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| [[1ezv]] - yCb + yCc1 + RISP + antibody<BR />
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| [[6giq]], [[6hu9]], [[6t0b]], [[6t15]], [[6ymx]] - yCb in respiratory complex – Cryo EM <BR />
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| [[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides<''BR />
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| [[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />
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| [[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />
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| [[2qjy]] - RsCb (mutant) + RsCc1 + RISP (mutant) + inhibitor<BR />
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| [[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />
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| [[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
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| [[7rja]], [[7rjb]], [[7rjc]], [[7rjd]], [[7rje]] - Cb in III2 complex – ''Candida albicans'' - Cryo EM <BR />
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| [[7e1v]] - MtCb in respiratory complex – ''Mycobacterium tuberculosis'' - Cryo EM <BR />
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| [[7e1w]], [[7e1x]] - MtCb in respiratory complex + drug - Cryo EM <BR />
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| [[7rh5]], [[7rh6]], [[7rh7]] - Cb in CIII2CIV2 complex – ''Mycobacterium smegmatis'' - Cryo EM <BR />
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| [[7q21]], [[7qhm]], [[7qho]] - Cb in CIII2CIV2 complex –'' Corynebacterium glutamicum'' - Cryo EM <BR />
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| == References == | | == References == |
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Cytochrome bc1 (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use cytochrome b6f in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.[1]
More details in Complex_III_of_Electron_Transport_Chain.
Structural highlights
Cbc1 is a dimeric protein composed of 11 proteins and cofactors which include heme-carrying proteins like cytochrome b (Cb) and cytochrome c1 (Cc1) and iron-sulfur cluster proteins like Rieske Fe-S protein (RISP). The iron containing moieties are heme, heme C (where vinyl side chain of heme are replaced by thioether) and Fe2S2. [2]
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3D structures of cytochrome bc1
Complex_III_of_Electron_Transport_Chain
References
