7w5q: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The ~~entry~~ 7w5q is ~~ON HOLD until Paper Publication~~

==The Kruppel-associated box (KRAB) domain of human zinc finger protein 568==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[7w5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W5Q FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w5q OCA], [https://pdbe.org/7w5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w5q RCSB], [https://www.ebi.ac.uk/pdbsum/7w5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w5q ProSAT]</span></td></tr>

[[Category: ~~Unreleased~~ Structures]]

</table>

== Function ==

[https://www.uniprot.org/uniprot/ZN568_HUMAN ZN568_HUMAN] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.[UniProtKB:E9PYI1]

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Han CW]]

[[Category: Jang SB]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7w5q is ON HOLD  until Paper Publication
+==The Kruppel-associated box (KRAB) domain of human zinc finger protein 568==
+<StructureSection load='7w5q' size='340' side='right'caption='[[7w5q]], [[Resolution|resolution]] 2.73&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7w5q]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7W5Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7W5Q FirstGlance]. <br>
-Description:
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7w5q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7w5q OCA], [https://pdbe.org/7w5q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7w5q RCSB], [https://www.ebi.ac.uk/pdbsum/7w5q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7w5q ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ZN568_HUMAN ZN568_HUMAN] Has transcriptional repression activity, partially through the recruitment of the corepressor TRIM28 but has also repression activity independently of this interaction. Essential during embryonic development, where it acts as direct repressor of a placental-specific transcript of IGF2 in early development and regulates convergent extension movements required for axis elongation and tissue morphogenesis in all germ layers. Also important for normal morphogenesis of extraembryonic tissues including the yolk sac, extraembryonic mesoderm and placenta. May enhance proliferation or maintenance of neural stem cells.[UniProtKB:E9PYI1]
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Han CW]]
+[[Category: Jang SB]]