8avg: Difference between revisions
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==Cryo-EM structure of mouse Elp123 with bound SAM== | |||
<StructureSection load='8avg' size='340' side='right'caption='[[8avg]], [[Resolution|resolution]] 4.01Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8avg]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8AVG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8AVG FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8avg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8avg OCA], [https://pdbe.org/8avg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8avg RCSB], [https://www.ebi.ac.uk/pdbsum/8avg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8avg ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ELP1_MOUSE ELP1_MOUSE] Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (By similarity). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:23717213). Regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation (PubMed:22854966). ELP1 binds to tRNA, mediating interaction of the elongator complex with tRNA (By similarity). May act as a scaffold protein that assembles active IKK-MAP3K14 complexes (IKKA, IKKB and MAP3K14/NIK) (By similarity).[UniProtKB:O95163][UniProtKB:Q06706]<ref>PMID:22854966</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Abbassi N]] | |||
[[Category: Biela A]] | |||
[[Category: Chramiec-Glabik A]] | |||
[[Category: Dobosz D]] | |||
[[Category: Gaik M]] | |||
[[Category: Glatt S]] | |||
[[Category: Hammermeister A]] | |||
[[Category: Indyka P]] | |||
[[Category: Jaciuk M]] | |||
[[Category: Kaszuba K]] | |||
[[Category: Koscielniak A]] | |||
[[Category: Kosinski J]] | |||
[[Category: Krutyholowa R]] | |||
[[Category: Lin T-Y]] | |||
[[Category: Rawski M]] | |||
[[Category: Schaffrath R]] | |||
[[Category: Scherf D]] | |||
Revision as of 08:18, 7 December 2022
Cryo-EM structure of mouse Elp123 with bound SAM
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