8b0j: Difference between revisions
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==CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis== | |||
<StructureSection load='8b0j' size='340' side='right'caption='[[8b0j]], [[Resolution|resolution]] 3.99Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8b0j]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0J FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0j OCA], [https://pdbe.org/8b0j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0j RCSB], [https://www.ebi.ac.uk/pdbsum/8b0j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0j ProSAT]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Chirgadze | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/RAPZ_ECOLI RAPZ_ECOLI] Modulates the synthesis of GlmS, by affecting the processing and stability of the regulatory small RNA GlmZ. When glucosamine-6-phosphate (GlcN6P) concentrations are high in the cell, RapZ binds GlmZ and targets it to cleavage by RNase E. Consequently, GlmZ is inactivated and unable to activate GlmS synthesis. Under low GlcN6P concentrations, RapZ is sequestered and inactivated by an other regulatory small RNA, GlmY, preventing GlmZ degradation and leading to synthesis of GlmS (PubMed:17824929, PubMed:23475961). Displays ATPase and GTPase activities in vitro. Can also hydrolyze pNPP (PubMed:19074378).<ref>PMID:17824929</ref> <ref>PMID:19074378</ref> <ref>PMID:23475961</ref> | ||
[[Category: Islam | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Escherichia coli K-12]] | |||
[[Category: Large Structures]] | |||
[[Category: Chirgadze DY]] | |||
[[Category: Hardwick HW]] | |||
[[Category: Islam MS]] | |||
[[Category: Luisi BF]] | |||
Revision as of 08:36, 7 December 2022
CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis
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