4kk2: Difference between revisions
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==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure== | ==Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure== | ||
<StructureSection load='4kk2' size='340' side='right' caption='[[4kk2]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='4kk2' size='340' side='right'caption='[[4kk2]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4kk2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Artemisia_spiciformis Artemisia spiciformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KK2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KK2 FirstGlance]. <br> | ||
</td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kk2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kk2 OCA], [https://pdbe.org/4kk2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kk2 RCSB], [https://www.ebi.ac.uk/pdbsum/4kk2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kk2 ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[[ | [https://www.uniprot.org/uniprot/FPPS1_ARTSI FPPS1_ARTSI] Catalyzes the sequential condensation of isopentenyl pyrophosphate (IPP) with the allylic pyrophosphates, dimethylallyl pyrophosphate (DMAPP), and then with the resultant geranylpyrophosphate (GPP) to the ultimate product farnesyl pyrophosphate (FPP). Has a 4.5 time greater affinity for GPP versus DMAPP.<ref>PMID:12782626</ref> [https://www.uniprot.org/uniprot/CHRDS_ARTSI CHRDS_ARTSI] Condenses two molecules of dimethylallyl diphosphate (DMAPP) to produce mainly an irregular monoterpene, chrysanthemyl diphosphate (CPP) and lower amounts of a branched monoterpene, lavandulyl diphosphate (LPP). CPP is a precursor of the pyrethrin insecticides. When incubated with isopentenyl diphosphate (IPP) and DMAPP, catalyzes three competing isoprenoid condensation reactions, a chain elongation to give geranyl diphosphate (GPP), a cyclopropanation to give CPP and a branching to give LPP.<ref>PMID:12782626</ref> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Artemisia spiciformis]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Al Obaidi NF]] | ||
[[Category: | [[Category: Almo SC]] | ||
[[Category: | [[Category: Bhosle R]] | ||
[[Category: | [[Category: Chowdhury S]] | ||
[[Category: | [[Category: Evans B]] | ||
[[Category: | [[Category: Gerlt JA]] | ||
[[Category: Hammonds | [[Category: Hammonds J]] | ||
[[Category: Hillerich | [[Category: Hillerich B]] | ||
[[Category: Imker | [[Category: Imker HJ]] | ||
[[Category: Love | [[Category: Love J]] | ||
[[Category: | [[Category: Poulter CD]] | ||
[[Category: | [[Category: Scott Glenn A]] | ||
[[Category: Seidel | [[Category: Seidel RD]] | ||
[[Category: Toro | [[Category: Toro R]] | ||
[[Category: Vetting | [[Category: Vetting MW]] | ||
[[Category: Washington | [[Category: Washington E]] | ||
Revision as of 08:55, 7 December 2022
Crystal structure of a chimeric FPP/GFPP synthase (TARGET EFI-502313c) from Artemisia spiciformiS (1-72:GI751454468,73-346:GI75233326), apo structure
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