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==Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6==
==Structure and receptor binding specificity of the hemagglutinin H13 from avian influenza A virus H13N6==
<StructureSection load='4kps' size='340' side='right' caption='[[4kps]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
<StructureSection load='4kps' size='340' side='right'caption='[[4kps]], [[Resolution|resolution]] 2.59&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kps]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/I77af I77af]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPS OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KPS FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kps]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/gull/Maryland/704/1977(H13N6)) Influenza A virus (A/gull/Maryland/704/1977(H13N6))]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KPS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KPS FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAL:BETA-D-GALACTOSE'>GAL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PRD_900067:3-sialyl-N-acetyllactosamine'>PRD_900067</scene>, <scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SIA:O-SIALIC+ACID'>SIA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kps OCA], [https://pdbe.org/4kps PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kps RCSB], [https://www.ebi.ac.uk/pdbsum/4kps PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kps ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kpq|4kpq]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=384499 I77AF])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kps FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kps OCA], [http://pdbe.org/4kps PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kps RCSB], [http://www.ebi.ac.uk/pdbsum/4kps PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kps ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/HEMA_I77AF HEMA_I77AF]] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.  
[https://www.uniprot.org/uniprot/HEMA_I77AF HEMA_I77AF] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Hemagglutinin|Hemagglutinin]]
*[[Hemagglutinin 3D structures|Hemagglutinin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: I77af]]
[[Category: Large Structures]]
[[Category: Gao, G]]
[[Category: Gao G]]
[[Category: Lu, X]]
[[Category: Lu X]]
[[Category: Qi, J]]
[[Category: Qi J]]
[[Category: Shi, Y]]
[[Category: Shi Y]]
[[Category: Receptor binding]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/4kps"