4kry: Difference between revisions

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==Structure of Aes from E. coli in covalent complex with PMS==
==Structure of Aes from E. coli in covalent complex with PMS==
<StructureSection load='4kry' size='340' side='right' caption='[[4kry]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
<StructureSection load='4kry' size='340' side='right'caption='[[4kry]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4kry]] is a 6 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRY OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KRY FirstGlance]. <br>
<table><tr><td colspan='2'>[[4kry]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KRY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KRY FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene>, <scene name='pdbligand=IMD:IMIDAZOLE'>IMD</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SEB:O-BENZYLSULFONYL-SERINE'>SEB</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SEB:O-BENZYLSULFONYL-SERINE'>SEB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kry OCA], [https://pdbe.org/4kry PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kry RCSB], [https://www.ebi.ac.uk/pdbsum/4kry PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kry ProSAT]</span></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4krx|4krx]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">aes, b0476, JW0465, ybaC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kry FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kry OCA], [http://pdbe.org/4kry PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4kry RCSB], [http://www.ebi.ac.uk/pdbsum/4kry PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4kry ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/AES_ECOLI AES_ECOLI]] Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.<ref>PMID:9576853</ref> <ref>PMID:11867639</ref> <ref>PMID:12374803</ref>
[https://www.uniprot.org/uniprot/AES_ECOLI AES_ECOLI] Displays esterase activity towards short chain fatty esters (acyl chain length of up to 8 carbons). Able to hydrolyze triacetylglycerol (triacetin) and tributyrylglycerol (tributyrin), but not trioleylglycerol (triolein) or cholesterol oleate. Negatively regulates MalT activity by antagonizing maltotriose binding. Inhibits MelA galactosidase activity.<ref>PMID:9576853</ref> <ref>PMID:11867639</ref> <ref>PMID:12374803</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Boos, W]]
[[Category: Large Structures]]
[[Category: Brosig, A]]
[[Category: Boos W]]
[[Category: Gerber, K]]
[[Category: Brosig A]]
[[Category: Schiefner, A]]
[[Category: Gerber K]]
[[Category: Acyl esterase]]
[[Category: Schiefner A]]
[[Category: Alpha/beta-hydrolase]]
[[Category: Hormone-sensitive-lipase family]]
[[Category: Hydrolase]]
[[Category: Inhibition of malt]]
[[Category: Phenylmethylsulfonyl-serine]]
Retrieved from "https://proteopedia.org/4kry"