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==Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition==
==Crystal structures of the LsrR proteins complexed with phospho-AI-2 and its two different analogs reveal distinct mechanisms for ligand recognition==
<StructureSection load='4l50' size='340' side='right' caption='[[4l50]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4l50' size='340' side='right'caption='[[4l50]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l50]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Ecoli Ecoli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L50 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L50 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l50]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L50 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=D8X:(2S)-2,3,3-TRIHYDROXY-6-METHYL-4-OXOHEPTYL+DIHYDROGEN+PHOSPHATE'>D8X</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=D8X:(2S)-2,3,3-TRIHYDROXY-6-METHYL-4-OXOHEPTYL+DIHYDROGEN+PHOSPHATE'>D8X</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l4y|4l4y]], [[4l4z|4l4z]], [[4l51|4l51]], [[4l5i|4l5i]], [[4l5j|4l5j]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l50 OCA], [https://pdbe.org/4l50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l50 RCSB], [https://www.ebi.ac.uk/pdbsum/4l50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l50 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">lsrR, ydeW, b1512, JW1505 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83333 ECOLI])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l50 OCA], [http://pdbe.org/4l50 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l50 RCSB], [http://www.ebi.ac.uk/pdbsum/4l50 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l50 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI]] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref>
[https://www.uniprot.org/uniprot/LSRR_ECOLI LSRR_ECOLI] Regulates transcription of many different genes. In the absence of autoinducer 2 (AI-2), represses transcription of the lsrACDBFG operon and its own transcription. In the presence of AI-2, LsrR is inactivated by binding phospho-AI-2, leading to the transcription of the lsr genes.<ref>PMID:15601708</ref> <ref>PMID:15743955</ref> <ref>PMID:17557827</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 4l50" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 4l50" style="background-color:#fffaf0;"></div>
==See Also==
*[[Transcriptional activator 3D structures|Transcriptional activator 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Ecoli]]
[[Category: Escherichia coli K-12]]
[[Category: Eo, Y]]
[[Category: Large Structures]]
[[Category: Ha, J H]]
[[Category: Eo Y]]
[[Category: Ryu, K S]]
[[Category: Ha JH]]
[[Category: Dna binding]]
[[Category: Ryu KS]]
[[Category: Dna transcriptional regulator]]
[[Category: Phospho-ai-2 binding]]
[[Category: Removed helix-turn-helix domain]]
[[Category: Sorc/deor family]]
[[Category: Transcription regulator]]
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