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==Structure of human mitochondrial 5'(3')-deoxyribonucleotidase==
==Structure of human mitochondrial 5'(3')-deoxyribonucleotidase==
<StructureSection load='4l6a' size='340' side='right' caption='[[4l6a]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
<StructureSection load='4l6a' size='340' side='right'caption='[[4l6a]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l6a]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6A OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L6A FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l6a]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L6A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L6A FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4l6c|4l6c]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6a OCA], [https://pdbe.org/4l6a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l6a RCSB], [https://www.ebi.ac.uk/pdbsum/4l6a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6a ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DNT2, NT5M ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l6a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l6a OCA], [http://pdbe.org/4l6a PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l6a RCSB], [http://www.ebi.ac.uk/pdbsum/4l6a PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l6a ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.  
[https://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Brynda, J]]
[[Category: Large Structures]]
[[Category: Pachl, P]]
[[Category: Brynda J]]
[[Category: Rezacova, P]]
[[Category: Pachl P]]
[[Category: Dephosphorylation]]
[[Category: Rezacova P]]
[[Category: Had-like]]
[[Category: Hydrolase]]
[[Category: Phosphorylation]]
[[Category: Protein conformation]]
[[Category: Sequence homology]]

Revision as of 09:34, 7 December 2022

Structure of human mitochondrial 5'(3')-deoxyribonucleotidase

4l6a, resolution 1.40Å

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