4l70: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older editNewer edit →
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
Line 1: Line 1:


==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352==
==Human artd3 (parp3) - catalytic domain in complex with inhibitor ME0352==
<StructureSection load='4l70' size='340' side='right' caption='[[4l70]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='4l70' size='340' side='right'caption='[[4l70]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[4l70]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L70 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4L70 FirstGlance]. <br>
<table><tr><td colspan='2'>[[4l70]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L70 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L70 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1V9:3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[(1S)-1-PHENYLPROPYL]PROPANAMIDE'>1V9</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1V9:3-(4-OXO-3,4-DIHYDROQUINAZOLIN-2-YL)-N-[(1S)-1-PHENYLPROPYL]PROPANAMIDE'>1V9</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gv0|4gv0]], [[4gv2|4gv2]], [[4gv4|4gv4]], [[4l6z|4l6z]], [[4l7l|4l7l]], [[4l7n|4l7n]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l70 OCA], [https://pdbe.org/4l70 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l70 RCSB], [https://www.ebi.ac.uk/pdbsum/4l70 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l70 ProSAT]</span></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ADPRT3, ADPRTL3, PARP3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/NAD(+)_ADP-ribosyltransferase NAD(+) ADP-ribosyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.2.30 2.4.2.30] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4l70 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l70 OCA], [http://pdbe.org/4l70 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4l70 RCSB], [http://www.ebi.ac.uk/pdbsum/4l70 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4l70 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN]] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>
[https://www.uniprot.org/uniprot/PARP3_HUMAN PARP3_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication. Binds DNA. May be involved in the regulation of PRC2 and PRC3 complex-dependent gene silencing.<ref>PMID:16924674</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
Line 23: Line 20:


==See Also==
==See Also==
*[[Poly (ADP-ribose) polymerase|Poly (ADP-ribose) polymerase]]
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Andersson, C D]]
[[Category: Large Structures]]
[[Category: Ekblad, T]]
[[Category: Andersson CD]]
[[Category: Elofsson, M]]
[[Category: Ekblad T]]
[[Category: Karlberg, T]]
[[Category: Elofsson M]]
[[Category: Lindgren, A E.G]]
[[Category: Karlberg T]]
[[Category: Linusson, A]]
[[Category: Lindgren AEG]]
[[Category: Schuler, H]]
[[Category: Linusson A]]
[[Category: Spjut, S]]
[[Category: Schuler H]]
[[Category: Thorsell, A G]]
[[Category: Spjut S]]
[[Category: Weigelt, J]]
[[Category: Thorsell AG]]
[[Category: Adp-ribosylation]]
[[Category: Weigelt J]]
[[Category: Diphtheria toxin like adp-ribose transferase]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
Retrieved from "https://proteopedia.org/4l70"