4l7c: Difference between revisions
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==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione== | ==Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione== | ||
<StructureSection load='4l7c' size='340' side='right' caption='[[4l7c]], [[Resolution|resolution]] 2.40Å' scene=''> | <StructureSection load='4l7c' size='340' side='right'caption='[[4l7c]], [[Resolution|resolution]] 2.40Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4l7c]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4L7C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4L7C FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1VW:2-{[(1S)-2-{[(1R,2S)-2-(1H-TETRAZOL-5-YL)CYCLOHEXYL]CARBONYL}-1,2,3,4-TETRAHYDROISOQUINOLIN-1-YL]METHYL}-1H-ISOINDOLE-1,3(2H)-DIONE'>1VW</scene>, <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4l7c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4l7c OCA], [https://pdbe.org/4l7c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4l7c RCSB], [https://www.ebi.ac.uk/pdbsum/4l7c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4l7c ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/KEAP1_HUMAN KEAP1_HUMAN] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 20: | Line 20: | ||
==See Also== | ==See Also== | ||
*[[Kelch-like protein|Kelch-like protein]] | *[[Kelch-like protein 3D structures|Kelch-like protein 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Albrecht | [[Category: Large Structures]] | ||
[[Category: Barker | [[Category: Albrecht C]] | ||
[[Category: Barker | [[Category: Barker JJ]] | ||
[[Category: Beaumont | [[Category: Barker O]] | ||
[[Category: Bromidge | [[Category: Beaumont E]] | ||
[[Category: Brookfield | [[Category: Bromidge S]] | ||
[[Category: Brooks | [[Category: Brookfield F]] | ||
[[Category: Ceska | [[Category: Brooks M]] | ||
[[Category: Courade | [[Category: Ceska T]] | ||
[[Category: Crabbe | [[Category: Courade JP]] | ||
[[Category: Duclos | [[Category: Crabbe T]] | ||
[[Category: Fryatt | [[Category: Duclos S]] | ||
[[Category: Jigorel | [[Category: Fryatt T]] | ||
[[Category: Jnoff | [[Category: Jigorel E]] | ||
[[Category: Kwong | [[Category: Jnoff E]] | ||
[[Category: Sands | [[Category: Kwong J]] | ||
[[Category: Smith | [[Category: Sands Z]] | ||
[[Category: Smith MA]] | |||
Revision as of 09:36, 7 December 2022
Structure of keap1 kelch domain with 2-{[(1S)-2-{[(1R,2S)-2-(1H-tetrazol-5-yl)cyclohexyl]carbonyl}-1,2,3,4-tetrahydroisoquinolin-1-yl]methyl}-1H-isoindole-1,3(2H)-dione
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