Sandbox Reserved 1739: Difference between revisions
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Deposition Author(s): Prongay, A.J., Guo, Z., Yao, N., Fischmann, T., Strickland, C., Myers Jr., J., Weber, P.C., Malcolm, B., Beyer, B.M., Ingram, R., Pichardo, J., Hong, Z., Prosise, W.W., Ramanathan, L., Taremi, S.S., Yarosh-Tomaine, T., Zhang, R., Senior, M., Yang, R., Arasappan, A., Bennett, F., Bogen, S.F., Chen, K., Jao, E., Liu, Y., Love, R.G., Saksena, A.K., Venkatraman, S., Girijavallabhan, V., Njoroge, F.G., Madison, V. | Deposition Author(s): Prongay, A.J., Guo, Z., Yao, N., Fischmann, T., Strickland, C., Myers Jr., J., Weber, P.C., Malcolm, B., Beyer, B.M., Ingram, R., Pichardo, J., Hong, Z., Prosise, W.W., Ramanathan, L., Taremi, S.S., Yarosh-Tomaine, T., Zhang, R., Senior, M., Yang, R., Arasappan, A., Bennett, F., Bogen, S.F., Chen, K., Jao, E., Liu, Y., Love, R.G., Saksena, A.K., Venkatraman, S., Girijavallabhan, V., Njoroge, F.G., Madison, V. | ||
Primary Structure: 180 amino acids. | Primary Structure: 180 amino acids. | ||
Secondary Structure ( | Secondary Structure: three alpha helices with 2 connecting loops. 9 anti-parallel beta sheets. Mixed barrel (13). | ||
Tertiary Structure | Tertiary Structure: | ||
8OHM for Hepatitis helicase: | 8OHM for Hepatitis helicase: | ||
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Deposition Author(s): Cho, H.S., Ha, N.C., Kang, L.W., Oh, B.H. | Deposition Author(s): Cho, H.S., Ha, N.C., Kang, L.W., Oh, B.H. | ||
Primary Structure: 620 amino acids. | Primary Structure: 620 amino acids. | ||
Secondary Structure | Secondary Structure: Beta sheets sandwiched between Alpha helices. | ||
Tertiary Structure(motif(s) present, domains):3 domains; domain 2 is linked to domains 1 and 3 by flexible linkers. 6 motifs; Walker A motif, the Phe loop, the Arg-clamp motif | Tertiary Structure(motif(s) present, domains):3 domains; domain 2 is linked to domains 1 and 3 by flexible linkers. 6 motifs; Walker A motif, the Phe loop, the Arg-clamp motif (14). | ||
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[12] Peter Simmonds. Variability of Hepatitis C Virus. Hepatology. Volume 21, Issue 2. February 1995. Pgs 570-583. ISSN 0270-9139. https://doi.org/10.1016/0270-9139(95)90121-3. | [12] Peter Simmonds. Variability of Hepatitis C Virus. Hepatology. Volume 21, Issue 2. February 1995. Pgs 570-583. ISSN 0270-9139. https://doi.org/10.1016/0270-9139(95)90121-3. | ||
(https://www.sciencedirect.com/science/article/pii/0270913995901213) | (https://www.sciencedirect.com/science/article/pii/0270913995901213) | ||
[13] Bressanelli, S.; Tomei, L.; Roussel, A.; Incitti, I.; Vitale, R. L.; Mathieu, M.; De Francesco, R.; Rey, F. A. Crystal Structure of the RNA-Dependent RNA Polymerase of Hepatitis C Virus. Proceedings of the National Academy of Sciences 1999, 96 (23), 13034–13039. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC23895/) | |||
[14] Frick, D. N.; Tan, S. L. In Hepatitis C viruses: Genomes and molecular biology; Horizon Bioscience: Norfolk U.K., 2006. (https://www.ncbi.nlm.nih.gov/books/NBK1614/) | |||