Sandbox Reserved 1739: Difference between revisions
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== Hepatitis C Helicase/Primase == | == Hepatitis C Helicase/Primase == | ||
== | <StrcutureSection load='8OHM' size='350' side='right' caption= 'Hepatitis C Helicase' scene='91/919048/Hepatitis_c_helicase/1'> | ||
<StructureSection load='2obq' size='350' side='right' caption='2OBQ' scene='91/919048/Hepatitis_c_primase/1'> | <StructureSection load='2obq' size='350' side='right' caption='2OBQ' scene='91/919048/Hepatitis_c_primase/1'> | ||
<Structure load='2obq' size='350' frame='true' align='right' caption='2OBQ scene='' />{{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | <Structure load='2obq' size='350' frame='true' align='right' caption='2OBQ scene='' />{{Sandbox_Reserved_Kim_Lane}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
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The relevance of Hepatitis C helicase/primase is that the helicase/protease combination in HCV is believed to play a pivotal role in the replication cycle of HCV. The helicase exists as a dimer, bearing mutations, and can be found in three different functional states (9). The three functional states include a substrate-unbound state, an ATP-bound state, and an NA-bound state. The presence of ATP transitions the protease from high NA binding affinity to low NA binding affinity. The cooperation of helicase/protease binding the DNA is affected by the length of the ss lattice, and the desired ss DNA length is around 22nt (3). | The relevance of Hepatitis C helicase/primase is that the helicase/protease combination in HCV is believed to play a pivotal role in the replication cycle of HCV. The helicase exists as a dimer, bearing mutations, and can be found in three different functional states (9). The three functional states include a substrate-unbound state, an ATP-bound state, and an NA-bound state. The presence of ATP transitions the protease from high NA binding affinity to low NA binding affinity. The cooperation of helicase/protease binding the DNA is affected by the length of the ss lattice, and the desired ss DNA length is around 22nt (3). | ||
== Structural highlights == | == Structural highlights == | ||
2OBQ: for | 2OBQ: for Hepatit<Structure load='<Structure load='Insert PDB code or filename here' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />' size='350' frame='true' align='right' caption='Insert caption here' scene='Insert optional scene name here' />is primase | ||
Method: X-Ray Diffraction. | Method: X-Ray Diffraction. | ||
Resolution: 2.50 Å. | Resolution: 2.50 Å. | ||
