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== Structural Highlights of HIV-1 protease==

There are hundreds of forms of HIV-1 protease. The basic HIV-1 protease contains two subunits that are dimers. These subunits contain an alpha helix, beta sheets running antiparallel to each other, and random coils. The beta sheets are in a jelly roll fold conformation. In the middle of the dimer is the active site. This molecule is HIV-1 protease PDB code 3hvp. Mutants have different molecules bound to the active site, making different mutants of HIV-1 protease. Some mutants are more easily controlled by drugs, such as protease inhibitors, while other mutations are more drug-resistant. It is difficult to determine which form of HIV-1 protease a person has, and each case of HIV-1 has to be treated on a case basis because there are so many mutants. The HIV-1 protease shown is a wild-type protease. [[Immunodeficiency virus protease]]

There are hundreds of forms of HIV-1 protease. The basic HIV-1 protease contains two subunits that are dimers. These subunits contain an alpha helix, beta sheets running antiparallel to each other, and random coils. <scene name='91/919044/Chain_a/1'>Text To Be Displayed</scene> The beta sheets are in a jelly roll fold conformation. In the middle of the dimer is the active site. This molecule is HIV-1 protease PDB code 3hvp. Mutants have different molecules bound to the active site, making different mutants of HIV-1 protease. Some mutants are more easily controlled by drugs, such as protease inhibitors, while other mutations are more drug-resistant. It is difficult to determine which form of HIV-1 protease a person has, and each case of HIV-1 has to be treated on a case basis because there are so many mutants. The HIV-1 protease shown is a wild-type protease. [[Immunodeficiency virus protease]]

==Structural Highlights of HIV-2 protease==

Sandbox Reserved 1735: Difference between revisions

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 == Structural Highlights of HIV-1 protease==
-There are hundreds of forms of HIV-1 protease. The basic HIV-1 protease contains two subunits that are dimers. These subunits contain an alpha helix, beta sheets running antiparallel to each other, and random coils. The beta sheets are in a jelly roll fold conformation. In the middle of the dimer is the active site. This molecule is HIV-1 protease PDB code 3hvp. Mutants have different molecules bound to the active site, making different mutants of HIV-1 protease. Some mutants are more easily controlled by drugs, such as protease inhibitors, while other mutations are more drug-resistant. It is difficult to determine which form of HIV-1 protease a person has, and each case of HIV-1 has to be treated on a case basis because there are so many mutants. The HIV-1 protease shown is a wild-type protease. [[Immunodeficiency virus protease]]
+There are hundreds of forms of HIV-1 protease. The basic HIV-1 protease contains two subunits that are dimers. These subunits contain an alpha helix, beta sheets running antiparallel to each other, and random coils. <scene name='91/919044/Chain_a/1'>Text To Be Displayed</scene> The beta sheets are in a jelly roll fold conformation. In the middle of the dimer is the active site. This molecule is HIV-1 protease PDB code 3hvp. Mutants have different molecules bound to the active site, making different mutants of HIV-1 protease. Some mutants are more easily controlled by drugs, such as protease inhibitors, while other mutations are more drug-resistant. It is difficult to determine which form of HIV-1 protease a person has, and each case of HIV-1 has to be treated on a case basis because there are so many mutants. The HIV-1 protease shown is a wild-type protease. [[Immunodeficiency virus protease]]
 ==Structural Highlights of HIV-2 protease==