Sandbox Reserved 1735: Difference between revisions

There are hundreds of forms of HIV-1 protease. The basic HIV-1 protease contains two subunits that are homodimers. These subunits contain beta sheets running antiparallel to each other, and random coils. <scene name='91/919044/Chain_a/1'>This is a subunit of HIV-1 protease PDB 3hvp.</scene> The beta sheets are in a jelly roll fold conformation. In the middle of the homodimer is the active site. Below the active site are the catalytic aspartates. <scene name='91/919044/Catalytic_aspartase/1'>Catalytic Aspartates.</scene> At the bottom of the molecule is the <scene name='91/919044/Dimerization_regions/1'>dimerization region</scene>.      Different mutants and wild types have different molecules bound to the active site, making different versions of HIV-1 protease. Some versions are more easily controlled by drugs, such as protease inhibitors, while other versions are more drug-resistant. It is difficult to determine which form of HIV-1 protease a person has, and each case of HIV-1 has to be treated on a case basis because there are so many mutants and wild types. [[Immunodeficiency virus protease]]