Sandbox Reserved 1759: Difference between revisions
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== Important amino acids== | == Important amino acids== | ||
The <scene name='93/934003/Protein_view_2/1'>ligand of interest</scene> in the MBD enzyme is called <scene name='93/934003/Ola/1'>Oleic acid (OLA)</scene> and is located within subunit A. OLA is hydrogen bonded to <scene name='93/934003/ | The <scene name='93/934003/Protein_view_2/1'>ligand of interest</scene> in the MBD enzyme is called <scene name='93/934003/Ola/1'>Oleic acid (OLA)</scene> and is located within subunit A. OLA is hydrogen bonded to <scene name='93/934003/Arg128/1'>Arg128</scene>. In addition to the hydrogen bonding between OLA and Arg128, OLA is also hydrogen bonded to a water molecule which is hydrogen bonded to Arg128 as well. Amino acids residue aspartate is important for catalytic activity and the stability of the protein. When Asp281 is replaced the enzyme experiences lose in decarboxylase function. When <scene name='93/934003/Asp309/1'>Asp309</scene> is replaced the enzyme experiences complete loss of MBD activity. | ||
== Structural highlights == | == Structural highlights == | ||
